GnRH

RNA-mediated cell type differentiation and behavior

Neuroscience Meeting Planner Now Available The Preliminary Program and Neuroscience Meeting Planner for Neuroscience 2014 are available. At the 2012 Meeting I learned that the microRNA/messenger RNA balance had emerged during the past decade to be the most likely regulator of all downstream effects on cell type differentiation. That inspired me to focus on what I knew about RNA-mediated events and put what we detailed about them in our 1996 Hormones and Behavior review into the context of a this…

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Behavior (2): All responses are RNA-mediated not genetically-determined

Diana Maria Petrosanu also asked: “who was the author of the article that had stolen your ideas?“ I cannot recall claiming that anyone had stolen our ideas or my ideas. See: Behavior: The first response is RNA-mediated not genetically-determined. In subsequent published works, I extended what we detailed about the molecular epigenetics of sex differences in cell types from yeasts to mammals via examples from model organisms of RNA-mediated cell type differentiation in different species. That is why I was…

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Pulses of olfactory/pheromonal input

Signal and noise: Spike correlations in the olfactory system by John Hewitt Excerpt: “The olfactory system is not so much a hard-wired telephone network where channels can be instantaneously specified and connected by number codes, and then used to transmit further codes. There is significant overgrowth and back-pruning in olfactory networks during development, and some ongoing cell replacement, but once etched, many of its larger features remain stable.” My comment: This comparison is meaningful: “…any message can not stand out…

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Pheromone-controlled thermodynamics and cancer

“If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” — Denis Noble Can thermodynamics help us better understand human cancers? Excerpt: “In a new study, UCLA researchers analyzed the gene-expression profiles of more than 2,000 patients and were able to identify cancer-specific gene signatures for breast, lung, prostate and ovarian cancers. The…

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Functional coding variants are not mutations

Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome “Conclusions: Our results validate the hypothesis that the SERT regulatory network harbors rare, functional variants that impact SERT activity and regulation in ASD, and encourages further investigation of this network as a site for additional functional variation that may impact ASD risk.” My comment: This open access article mentions mutations, but the title and conclusion correctly infer that coding “variants”…

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Mirror neurons and microRNA: theory vs biological facts

Mirror neurons through the lens of epigenetics to be published in Trends in Cognitive Sciences Volume 17, Issue 9, September 2013, Pages 450–457. epub on 14 August 2013 Abstract excerpt: … we propose a new evolutionary developmental biology (evo-devo) perspective, which predicts that environmental differences early in development should produce variations in mirror neuron response patterns, tuning them to the social environment. See Figure 1: Excerpt: “…the early social experience produces modifications in gene expression through epigenetic marks, such as…

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Are pheromones responsible for human body odour assessment?

Can You Smell Yourself? by Sarah C. P. Williams on 22 January 2013, 5:10 PM Excerpt: “Other molecules the human body produces could also influence individual smells and scent preferences, Zufall says. The individuality of people’s microbiomes—the collection of microbes living in and on us—could also be linked to the body’s odor or preferences, Wedekind says. “We just don’t know the full physiology yet,” he said, “But this is a good start.” My comment: The full physiology has been detailed.…

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