gonadotropin-releasing hormone

Biologically uninformed science idiot: Self-defense (2)

Summary: “Construction of automata” is the operative phrase. But you must be willing to believe that the automata create themselves outside the context of the creation of sunlight and light-activated endogenous substrates in all cell types of all living genera. Causation, constructors and codes A formal definition of codes in general, and organic codes in particular, allows the relational diagram to be extended so as to capture this translation of formal cause into process. The extended relational diagram is used…

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Odor activation of ATP (1)

Serious scientists start from the levels of biological organization required to link atoms to ecosystems in all living genera. They must link what is known about quantized energy to subatomic particles. See for example slide number 6 from: Human Pheromones: Linking Neuroendocrinology and Ethology (revisited)  (2010) Subatomic particles must be the link to the creation of ATP synthase, which must link the creation of ATP to the creation of RNA. See McEwen et al., (1964) Dependence of RNA synthesis in…

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Ecological adaptation: a new definition of heredity (4)

Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity (2018) Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. The restructuring during metamorphosis is biophysically constrained by feedback loops that link olfaction from food odors and pheromones to the creation of enzymes in bacteria and the secretion of the vertebrate decapeptide hormone GnRH (gonadotropin releasing hormone). See: Gonadotropin-releasing hormone agonist binding in…

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The MicroRNAome Strikes Back: A Sokalian hoax (3)

One way to recognize a Sokalian hoax is to determine whether the claims can be linked from gravity or from the speed of light on contact with water to feedback loops that biophysically constrain viral latency and all biodiversity in all living genera. See: Feedback loops link odor and pheromone signaling with reproduction See for comparison: Chiromagnetic nanoparticles and gels Reported as: Nanoparticle gel controls twisted light with magnetism The trick, the researchers found, was to twist the nanoparticles themselves by coating them…

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For God and Country

Energy-dependent structure and function: Until death (3)

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That suggests the human specific COMT Val158Met substitution may be important to those who know very little about suicide prevention. For instance, see: The catechol-o-methyltransferase Val158Met polymorphism…

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For God and Country

Energy-dependent structure and function: Until death (2)

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to the suicide rate in veterans who have returned from military service overseas with viruses. The viruses clearly link energy-dependent changes in the microRNA/messenger RNA balance…

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For God and Country

Energy-dependent structure and function: Until death (1)

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

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Host-derived creation of all pathology (2 of 2)

Summary: All serious scientists know that all epigenetic diversity is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. See for comparison: Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.” A Bacterial Messenger Molecule Extends Healthspan …indole,…

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Irreconcilable differences: food energy vs de novo assembly

Developmental dynamics and contemporary evolutionary psychology: status quo or irreconcilable views? Reply to Bjorklund (2003), Krebs (2003), Buss and Reeve (2003), Crawford (2003), and Tooby et Al. (2003). The authors argue that evolutionary psychology currently offers no coherent framework for how to integrate genetic, environmental, and experiential factors into a theory of behavioral or cognitive phenotypes. An evolutionary perspective on the systems of adaptive immunity We propose a revival of the concept of the ‘Big Bang’ of vertebrate immunity, arguing…

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Energy-dependent physical and biophysical constraints (9)

Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells Excerpt 1) The chromatin structure of DNA determines genome compaction and activity in the nucleus. My comment:…

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