RNA-Mediated

7/29/21 I linked fixation of one amino acid substitution, EDAR V370A from the diet of human populations in East and central China to the New World during the past 5-10K years of ecological adaptations via https://nature.com/news/past-5-000-years-prolific-for-changes-to-human-genome-1.11912 WHO still hates me for doing that. How? “The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.” Clearly, there has never been support for stupid theories about the emergence…

The microRNA-mediated fight against COVID-19 (1)

August 21, 2020

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA interference, What's in the News

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

Biologically uninformed science idiot: Self-defense (2)

June 2, 2018

Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA–Mediated Epigenetic Heredity, Subatomic

Summary: “Construction of automata” is the operative phrase. But you must be willing to believe that the automata create themselves outside the context of the creation of sunlight and light-activated endogenous substrates in all cell types of all living genera. Causation, constructors and codes A formal definition of codes in general, and organic codes in particular, allows the relational diagram to be extended so as to capture this translation of formal cause into process. The extended relational diagram is used…

Odor activation of ATP (1)

March 26, 2018

Adaptations, Diseases & Disorders, Ecology

Serious scientists start from the levels of biological organization required to link atoms to ecosystems in all living genera. They must link what is known about quantized energy to subatomic particles. See for example slide number 6 from: Human Pheromones: Linking Neuroendocrinology and Ethology (revisited) (2010) Subatomic particles must be the link to the creation of ATP synthase, which must link the creation of ATP to the creation of RNA. See McEwen et al., (1964) Dependence of RNA synthesis in…

Ecological adaptation: a new definition of heredity (4)

March 9, 2018

Adaptations, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations

Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity (2018) Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. The restructuring during metamorphosis is biophysically constrained by feedback loops that link olfaction from food odors and pheromones to the creation of enzymes in bacteria and the secretion of the vertebrate decapeptide hormone GnRH (gonadotropin releasing hormone). See: Gonadotropin-releasing hormone agonist binding in…

The MicroRNAome Strikes Back: A Sokalian hoax (3)

January 24, 2018

Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity

One way to recognize a Sokalian hoax is to determine whether the claims can be linked from gravity or from the speed of light on contact with water to feedback loops that biophysically constrain viral latency and all biodiversity in all living genera. See: Feedback loops link odor and pheromone signaling with reproduction See for comparison: Chiromagnetic nanoparticles and gels Reported as: Nanoparticle gel controls twisted light with magnetism The trick, the researchers found, was to twist the nanoparticles themselves by coating them…

Energy-dependent structure and function: Until death (3)

October 11, 2017

Autophagy, RNA Directed

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That suggests the human specific COMT Val158Met substitution may be important to those who know very little about suicide prevention. For instance, see: The catechol-o-methyltransferase Val158Met polymorphism…

Energy-dependent structure and function: Until death (2)

October 11, 2017

Autophagy, RNA Directed

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to the suicide rate in veterans who have returned from military service overseas with viruses. The viruses clearly link energy-dependent changes in the microRNA/messenger RNA balance…

Energy-dependent structure and function: Until death (1)

October 11, 2017

Autophagy, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, Variations

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

Host-derived creation of all pathology (2 of 2)

August 29, 2017

Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News