GPCR

Trump’s appeal to common sense (2)

See: Trump’s appeal to common sense Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation To our knowledge, this is the first study to use a genetic mouse model to simultaneously map Gpr182 localization patterns and elucidate novel physiological functions for the negative regulation of intestinal proliferative capacity, especially during regeneration and adenoma formation. Future studies to identify the ligand for this exciting and physiologically relevant orphan GPCR [G protein-coupled receptor] will shed light on its tractability as…

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Displays of ecological adaptation

A cinematic approach to drug resistance In a creative stroke inspired by Hollywood wizardry, scientists have designed a simple way to observe how bacteria move as they become impervious to drugs. The experiments are thought to provide the first large-scale glimpse of the maneuvers of bacteria as they encounter increasingly higher doses of antibiotics and adapt to survive—and thrive—in them. My comment: The nutrient-dependent pheromone-controlled ecological adaptations were reported as if mutation-driven evolution of bacteria had occurred. See for comparison:…

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Energy-dependent cellular communication

Communication shapes sensory response in multicellular networks Significance Cells routinely sense and respond to their environment, and they also communicate with each other. Exactly how communication impacts sensing remains poorly understood. We study a population of fibroblast cells that responds to a chemical stimulus (ATP) and communicates by molecule exchange. Combining experiments and mathematical modeling, we find that cells exhibit calcium oscillations in response to not only the ATP stimulus but also, increased cell–cell communication. Our results show that, when…

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Energy-dependent RNA methylation (6)

After I published Nutrient-dependent/pheromone-controlled adaptive evolution: a model, Lynnette Ferguson and Justin O’Sullivan invited me to submit this review of nutritional epigenetics for inclusion in a special issue of the journal “Nutrients.” Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (April 10, 2014) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes…

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Molecular Diagnostics: What is unprotected life?

Facile Recoding of Selenocysteine in Nature Abstract excerpt: This illustrates the ease by which the genetic code may evolve new coding schemes, possibly aiding organisms to adapt to changing environments, and show the genetic code is much more flexible than previously thought. My comment: It also refutes the ridiculous theories of neo-Darwinists, by placing ecological variation and ecological adaptation into the context of how nutrient-dependent RNA-mediated events are linked from the innate immune system to the physiology of reproduction and…

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Amino acid substitutions, stress, and human behavior

Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity Excerpt: …33% of the human population present a BDNF Val66Met SNP that leads to a valine-to-methionine substitution in the BDNF protein at codon 66, and this SNP has been associated with increased susceptibility to development of stress-related disorders (21, 22). Reported as: Newly discovered windows of brain plasticity may help with treatment of stress-related disorders Excerpt: The researchers also identified the molecule regulating…

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RNA-mediated everything

Odorant receptor gene choice and axonal wiring in mice with deletion mutations in the odorant receptor gene SR1 Abstract: In the mouse, a mature olfactory sensory neuron (OSN) of the main olfactory epithelium (MOE) expresses one allele of one of the 1200 odorant receptor (OR) genes in the genome. The mechanisms that underlie the one receptor–one neuron rule remain poorly understood. A popular experimental paradigm for OR gene choice is to delete an OR coding region by gene targeting or…

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