Greg Bear

Scientists lose. A sci-fi author gains credibility

Phage spread antibiotic resistance Excerpt 1) nearly half of the 50 chicken meat samples purchased from supermarkets, street markets, and butchers in Austria contained viruses that are capable of transferring antibiotic resistance genes from one bacterium to another—or from one species to another. Excerpt 2) Until recently, transduction of antibiotic resistance via phage was assumed to be a very minor source of the spread of resistance, said Hilbert. My comment: Bacteriophages were linked to cell type differentiation in species from…

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An epigenetic mark links algae, worms, and flies

New Epigenetic Mark Found on Metazoan DNA Three studies identify roles for N6-methyladenosine in algae, worms, and flies. By Jenny Rood | April 30, 2015 Excerpt (with my emphasis): “In bacteria, 6mA marks the template strand during DNA replication, enabling a cell to spot errors and regulate the cell cycle. The modification also helps differentiate bacterial DNA from viral genomic material, which lacks methylation.” My comment: The ability of a cell or organism to recognize self vs other differences enables…

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Re-inventing a completely new thing

Ancient Viruses, Once Foes, May Now Serve as Friends Excerpt 1) “A new study published in the journal Nature on Monday suggests that endogenous retroviruses spring to life in the earliest stages of the development of human embryos. The viruses may even assist in human development by helping guide embryonic development and by defending young cells from infections by other viruses.” Excerpt 2) “Dr. Wysocka acknowledged that the evidence she and her colleagues had gathered was only suggestive at this…

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Nutrient-dependent RNA interference (2)

Cell type differentiation in all genera begins with the recognition of self vs non-self differences such as those we attributed to RNA-mediated pheromone-controlled sex differences in the cell types of species from yeasts to mammals. See: From Fertilization to Adult Sexual Behavior Excerpt: “Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and…

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The Darwin Code by Greg Bear

“The Darwin Code: Intelligent Design without God” by Greg Bear, who wrote on April 14, 2015: “Happy to have this version of the talk posted. It’s a variation on the talk I gave at the American Philosophical Society in 2004, and a few times after that.  This one was delivered in Seattle at the Primate Genome Conference in the late 2000s.” —————————————— “Sometimes we hear explorers saying that the adventure is over, the territory has been mapped, there’s nothing more…

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A genetic variant refutes neo-Darwinism

Summary: They link a single nucleotide polymorphism (SNP) to a genetic variant that decreases viability of an embryo, without linking a nutrient-dependent RNA-mediated amino acid substitution to pheromone-controlled cell type differentiation that begins in the embryo and continues throughout the life history transitions of invertebrates and vertebrates. A Benefit of Failed Pregnancy? This genome-wide association study revealed “…a striking link between mitotic aneuploidy and a single nucleotide variant (SNP rs2305957) on chromosome 4 of maternal genomes.” Excerpt: “There’s this genetic…

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2 genes in 2 species (too expensive and too insignificant)

Characterisation of two Neurogenin genes from the brook lamprey Lampetra planeri and their expression in the lamprey nervous system by Ricardo Lara Ramirez et al. Abstract excerpt: “Here we report the isolation of two Neurogenin genes, LpNgnA and LpNgnB, from the lamprey Lampetra planeri. Phylogenetic analyses show both genes have orthologues in other lamprey species and in a hagfish.” My comment: “…the identity of a single functional GPH [glycoprotein hormone] of the hagfish, hagfish GTH, provides critical evidence for the…

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Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs

Of Cells and Limits Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement. By Anna Azvolinsky | March 1, 2015 Excerpt: The rejection letter came from Francis Peyton Rous who received the Nobel Prize a few years later for his discovery of chicken tumor viruses. My comment: My 2014 invited review of nutritional epigenetics detailed how differences in the microRNA/messenger…

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Jumping back: Science or Pseudoscience? (2)

See: Jumping back: Science or Pseudoscience? European Science’s Great Leap Backward inferred that evolutionary theory is evidence-based science: Excerpt: “… the U.S. can claim no superiority in our approach to evidence-based science, as demonstrated by the fact that nearly half of the country rejects the “theory” of evolution…” This article attests to the need to substitute evidence-based science: Leading Activist Apologizes For Starting Anti-GMO Movement Excerpt: “But what about mixing genes between unrelated species? The fish and the tomato? Turns…

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Intelligent viruses and cancers?

The Very Intelligent Ebola Virus Takes Front and Center Excerpt 1) “Ebola doesn’t enter the nucleus. It uses the cell’s machinery of ribosomes and transfer RNA to make proteins from the viral messengerRNA.” Excerpt 2) “Normally, mechanisms inside the nucleus have complex relations with messenger RNA and the alternative RNA editing process (see RNA alternative editing post). Specific protein complexes help splice the messengerRNA before it is sent from the nucleus to the ribosomes in the cytoplasm to make proteins.”…

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