Health

Polymaths and paradigm shifts: from Asimov to Bear (4)

Saying Goodbye to the RNA World Theory RNA has a limited ability for catalysis compared to peptides, and would have struggled to maintain its catalytic activity under the changing temperature conditions of early Earth. Carter and Wills also argued that if an RNA world existed, it would have been unlikely for it to incorporate peptides later on. See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)…

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Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.

Nothing known to serious scientists links anything except energy-dependent changes in chirality to autophagy and biodiversity via RNA-mediated amino acid substitutions that differentiate all cell types in all living genera. That fact forces pseudoscientists to invent new terms to confuse the biologically uninformed masses who were taught to believe in the neo-Darwinian pseudoscientific nonsense of mutation-driven evolution. Autophagy in the liver: functions in health and disease  See the section: Regulation of autophagy by amino acids See for comparison: From Fertilization…

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The human virome (revisited)

From October 2013: Describing the Silent Human Virome with an Emphasis on Giant Viruses “…viruses infect all domains of life, including bacteria, archaea and eukaryotes, and are found in all ecological niches [2]. This pleiotropic distribution on our planet allows viruses to play the role of ‘natural motors’ that drive global energy and nutrient cycling [3,4].” My comment: The portrayal of viruses as ‘natural motors’ is made outside the context of the fact that the energy-dependent changes attributed to the…

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Researchers rename, reshuffle, and reveal their ignorance

New Species Abound Re: Researchers renamed, reshuffled, and revealed species… Evidently, NEW SPECIES is part of a misleading headline placed into the context of some that EMERGED. Adapted/updated from my comments on Beyond DNA See: A Cellular System for Spatial Signal Decoding in Chemical Gradients This cellular system links the sun’s anti-entropic force and the virucidal effect of UV light to the strategic cellular defense system of all cell types. Researchers began studying this particular molecule because the RNA kicks…

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Mystery machine vs model

See: Mystery machine vs medical intelligence Is nutrition the future of brain health? Excerpt: Steindler’s focus on the link between nutrition and neurodegenerative diseases is unique in the field. My comment: If he has limited his claims to those associated only with neurodegenerative diseases, his focus is too narrow. Unfortunately, narrow focus is common among specialists. Their focus makes them specialists, and without them generalists could not connect the specialties to healthy longevity and/or pathology. Not just brain health or…

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Implicating microRNAs in cancer

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis Reported as: In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution Excerpt: “Unexpectedly, the screen also implicated several microRNAs — small RNA segments that are functional in the cell. More experimental work remains to fully explore the genes and microRNAs uncovered in the screen.” It is the perturbed balance of viral microRNAs and nutrient-dependent microRNAs that obviously makes the difference between RNA-directed DNA methylation and…

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An epigenetic trap (the prequel)

See also: An epigenetic trap (the sequel) Excerpt: “Support for the link from one epigenetic trap to cell type differentiation was included in the molecular epigenetics section of our 1996 review, which detailed how RNA-mediated chromatin remodeling occurs.” My comment: One epigenetic trap leads to the de novo creation of olfactory receptor genes and cell type differentiation. See also: Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. The first epigenetic trap links the sun’s biological energy to cell type…

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One test of bioenergetic health?

Success of new-generation metabolo-therapies in personalized medicine depends on measuring bioenergetic health Excerpt: “In one test, a comprehensive measure of energetic health, or its disease-related deterioration, can now be made. The prognostic and diagnostic value of bioenergetic measurements in patients is still unknown, but recent findings support an emerging concept that circulating leukocytes and platelets can serve as the “canary in the coal mine” by acting as early sensors or predictive biomarkers of metabolic function under conditions of chronic stress…

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RNA-mediated species specificity

Species-Specific Scientists uncover striking differences between mouse and human gene expression across a variety of tissues. By Jyoti Madhusoodanan | November 17, 2014 Excerpt: “…results published today (November 17) in PNAS reveal widespread differences between human and mouse gene expression, both in protein-coding and noncoding genes, suggesting that understanding these disparities could help explain fundamental differences in the two species’ physiology.” My comment:  See also: Physiology is rocking the foundations of evolutionary biology  Conclusion: “Perhaps the elegant mathematics and the…

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