healthy longevity

Vietnam Veterans and others with glioblastoma

The Agent Orange Widows Club After their husbands died of an aggressive brain cancer, the widows of Vietnam veterans have found one another as they fight the VA for benefits. See also: Vietnam Veterans with Glioblastoma Multiforme Stage 4 Brain Cancer This post was removed: Targeting NF-κB in glioblastoma: A therapeutic approach This is the level of complexity that the VA needs to understand and link to the treatment of this aggressive cancer, which is obviously caused by virus-driven energy theft.…

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Energy-dependent sensory maps (1996-2016)

Developmental broadening of inhibitory sensory maps My summary: They help to detail how olfactory input causes the energy-dependent de novo creation of sensory maps, which are representations of the external world. The experience-dependent representations link chemotaxis and phototaxis to biophysically constrained behavior. The representations are systematically organized in brain structures throughout development. Simply put, the maps are links from the epigenetic landscape to the physical landscape of supercoiled DNA in organized genomes. By investigating how ongoing neurogenesis in the mouse…

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Explorers who do not know what is known (2)

See: Explorers who do not know what is known See also: Energy-dependent polycombic ecological adaptation Now see: The B/Z reaction, and the problem with peer review December 9. 2016 by John Leonard … oscillating chemical reactions predictable by mathematical formula are partially responsible for organizing cells to form organs, bone, and tissue. Alan Turing didn’t live to see the publication of evidence that would have validated his theory almost immediately. …when Belousov attempted to have his research published in 1951,…

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Autophagy is the antiphage defense strategy

The “Antiphage Defense Strategy” in Vibrio anguillarum is called autophagy by many serious scientists. It links nutrient energy-dependent pheromone-controlled quorum sensing to viral latency, healthy longevity, symbiosis, reproduction, and biodiversity from microbial species to humans. For an evolutionary approach to energy-dependent autophagy that fails to address any aspect of how virus-driven energy theft causes all pathology see: (12/7/16) Part I: Living together: The symbiosis of host-microbial interactions (12/7/16) See also: 12/7/16 ….McFall-Ngai tells the story of a symbiosis between the…

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Combating evolution: Battlefield medicine vs politicized science

A steady decline in the number of pages read on this domain is paired with an increased bounce rate each time I post anything that pits the science of creation against the pseudoscientific nonsense of neo-Darwinian theories. If this domain were used in the context of a social science experiment, the statistics would show how theories have left the USA relatively defenseless against the threat of gene-editing technology, which has has been advanced in countries where students are not taught…

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Metabolic Phenotyping Research

Global Consortium to Conduct Metabolic Phenotyping Research Consortium members in six countries will use chromatography, mass spectrometry, and other technologies to conduct metabolic phenotyping research that examines the dynamic interactions between genes, environments, microbiomes, diets, and lifestyles, and their collective impact on disease. My Predictions. 1. They will link energy as information to healthy longevity. 2. They will report their findings as if they discovered new molecular mechanisms. 3. The mechanisms will link the anti-entropic virucidal energy of ultraviolet light…

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Energy-dependent coulombic, autophagic, polycombic healthy longevity

Mitophagy is the selective degradation of mitochondria by autophagy. See also this excerpt: Disorders in energy creation by mitochondria can cause cellular degeneration… Mitochondria do not create energy.  They link the creation of the sun’s anti-entropic virucidal energy to RNA-mediated cell type differentiation via biophysically constrained DNA repair. Energy-dependent autophagy links mitophagy to supercoiled DNA via the innate immune system and RNA-mediated repair of damaged DNA. Repair is nutrient-energy dependent. Separating mitophagy from autophagy is one way to prevent people…

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Energy-dependent purifying selection / autophagy (3)

See also: Energy-dependent purifying selection / autophagy (2) But see: Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters Re: “…the interactomes of 31,253 annotated promoters in 17 human primary blood cell types.” Excerpt: Here, we link thousands of GWAS SNPs to their putative target genes and prioritize more than 2,500 potential disease-associated genes, three-quarters of which were not previously implicated. Reported as: Researchers identify missing links that connect human DNA variation with disease My comment:…

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Energy-dependent purifying selection / autophagy (6)

See: Energy-dependent purifying selection / autophagy (5) Simply put all aspects of biophysically constrained energy-dependent cell type differentiation must first be linked from the physiology of reproduction to ecological adaptations, or they must be linked from energy theft to the evolution of pathology. See for contrast and comparsion: Finding your diagnosis in the brave new world of genetics-based medicine by John Hewitt Excerpts: Typically all they have is a stack of diffuse paper reports and xeroxed publications from the primary…

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Virus-driven mutation or amino acid substitution

A computer program just ranked the most influential brain scientists of the modern era Excerpt: “My first thought was, ‘Who could I tell without appearing immodest?’” he said. “I then realized the only people who would want to hear about this are my children!” My comment: Oxytocin-related peptides are 9-13 amino acids long, but they can be recognized in genomic sequences. That allows them to be placed into the context of claims that link the nutrient energy-dependent de novo creation…

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