healthy longevity

RNA splicing, genetic variation, and disease

More than 600 blog posts on this domain attest to the fact that nutrient energy-dependent RNA-mediated cell type differentiation is the key to healthy longevity in all living genera. Only those who have missed the accurate representations of others who have linked angstroms to ecosystems via the innate immune system, the physiology of reproduction, and supercoiled DNA will continue to place RNA splicing into the context of disease, without acknowledging that RNA splicing is the key to Precision Medicine. RNA…

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The Light and Darkness of “Evolution 2.0”

The light of evolution in the oft-cited work by Dobzhansky (1973) is the energy from sunlight. The sun’s biological energy links its anti-entropic virucidal epigenetic effects to RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera. Excerpt from Dobzhansky (1973)  …the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla. ( p.…

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Blood test links atoms to ecosystems

New blood test may expand scope of liquid biopsies Excerpt: During cell death, the DNA gets chopped into small pieces by enzymes that like to cut in the easily accessible, unprotected sections of DNA in between the nucleosomes. My comment: The test links ecological variation to nutrient-dependent RNA-mediated DNA repair via microRNAs and adhesion proteins. The adhesion proteins link supercoiled DNA to protection from virus-driven entropy in the organized genomes of all living genera. The organized genomes are linked from…

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RNA-mediated theory killers (4)

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Excerpt: At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for cancer diagnosis. My comment: The SLC19A3 microRNA was mentioned in the context of cancer and brain development in The impact of new technologies on clinical decision-making in health care. The location of the base…

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RNA-mediated theory killers (2)

RNA-mediated theory killers… This is a continuation that will become a series that links the million dollar paradox to the $100,000 prize offered for finding the origin of information at Evolution 2.0, which obviously will be a continuation of Schrodinger’s claims and Dobzhansky’s claims along with the claims of others I have repeatedly mentioned here. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Reported as: Lifelong learning is made possible by recycling of histones Excerpt: “Histones and their…

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Sulfated steroids and RNA-mediated identity codes

Sulfated steroids and RNA-mediated identity codes Summary: In two studies of human pheromones we linked a mixture of androsterone and androstenol to increased flirtatious behavior and reports of increased attraction to the male wearing the mixture. This blog posts explains the reason for the use of those two chemicals in the context of what is currently known to serious scientists about cell type differentiation in all living genera. Excerpt: Sequencing both microRNA and mRNA enabled us to identify changes on…

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Sensationalizing no new mechanism

Scientists discover new mechanism that protects brain stem cells against aging-induced damage Excerpt: Sebastian Jessberger says: This is an exciting new mechanism involved in stem cell division and aging. But as of now we are only just beginning to understand the molecular constituents and the true meaning of the barrier for stem cell division in the brain. One key question to be answered is whether the barrier is established in all somatic stem cells of the body. My comment: There…

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MicroRNA controlled growth and brain development

Navigable networks as Nash equilibria of navigation games Nature Communications | Article  Open Excerpt: Here we show that the ideal maximally navigable networks do share some basic structural properties with the Internet, E.coli metabolic network, English word network, US airport network, the Hungarian road network and a structural network of the human brain. Reported as: Researchers find the organization of the human brain to be nearly ideal Excerpt: “An optimal network in the brain would have the smallest number of…

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