CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem … Virus-driven genome engineering causes cancer?
Summary: RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong. I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. … The eternal significance of microRNAs (3)
Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular … Can protein folding chemistry be understood by theorists?
Introduction by Eugene Daev Since the very beginning, I suggested that state of stress, which accompanied by sharp hormonal changes (Selye, 1950), ought to have an effect at the genetic level. My group has focused on pheromonal destabilization of mouse genome. We used the urinary pheromones from conspecific males and/or females as sex-specific stressors. Cytogenetic … Eugene V. Daev: Chronology
Practopoiesis A thought results primarily from an adjustment of the brain hardware, and not from a computation executed by that hardware. My comment: The adjustments of the brain hardware integrate RNA-mediated events that include gene duplication and fixation of amino acid substitutions. The nutrient-dependent gene duplications and substitutions link the epigenetic landscape to the physical … Hematopoiesis and practopoiesis
