Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

Read More
An evolutionary theory killer

The eternal significance of microRNAs (3)

Summary:  RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong.   I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. When trapped by their ridiculous theories, they no longer kick, scream, or bite (like weasels). They participate in so-called marches like the 2018 March for…

Read More

Can protein folding chemistry be understood by theorists?

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular function, “but the nuances of biology rest in how individual isoforms are regulated,” Aye said. Natural selection for energy-dependent codon optimality regulates the creation of…

Read More

Eugene V. Daev: Chronology

Introduction by Eugene Daev Since the very beginning, I suggested that state of stress, which accompanied by sharp hormonal changes (Selye, 1950), ought to have an effect at the genetic level. My group has focused on pheromonal destabilization of mouse genome. We used the urinary pheromones from conspecific males and/or females as sex-specific stressors. Cytogenetic pheromonal effects we discovered supported this idea. We showed the genetic effects (mutagenic and antimutagenic) in vital peripheral organs (bone marrow and germ cells) in…

Read More

Hematopoiesis and practopoiesis

Practopoiesis A thought results primarily from an adjustment of the brain hardware, and not from a computation executed by that hardware. My comment: The adjustments of the brain hardware integrate RNA-mediated events that include gene duplication and fixation of amino acid substitutions. The nutrient-dependent gene duplications and substitutions link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via their physiology of reproduction. The idea that everything known about nutrient-dependent…

Read More