hemoglobin

Predictable idiosyncratic evolved convergence

October 23, 2016
James Kohl
Adaptations, Alternative Splicings, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Predictable convergence in hemoglobin function has unpredictable molecular underpinnings Excerpt: …predictable changes in biochemical phenotype do not have a predictable molecular basis. My comment: Biochemical phenotypes are predicted at every level of examination that starts with hydrogen-atom energy transfer in DNA base pairs in solution, and at least two of these authors know that. See: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin June 14, 2013 Excerpt: Fig. 2 Difference in the network of hydrogen bonds between high- and low-altitude…

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The Mind’s Eyes (revisited)

June 12, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Author’s copy: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences (2007) Abstract: The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self.  Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response.  The organization and activation of this neuroendocrine response modulates the concurrent maturation of the mammalian neuroendocrine system, the reproductive system, and the central nervous system during the development of sexual preferences that…

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Energy-dependent biodiversity

May 21, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Abstract excerpt: …the same activating principles used for decades to make simple C–N (amide) bonds from carboxylic acids with loss of water can be used to make C–C bonds… Conclusion: The ready availability of numerous carboxylic acids (which are easily converted to esters) contributes to the reaction’s versatility. My comment: Light energy-induced chemical reaction versatility links what is known about biophotonics to the physiology of energy-dependent pheromone-controlled reproduction in…

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Bringing RNA back to epigenetics (20 years later)

February 19, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, Variations
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Has Contemporary Academia Outgrown the Carl Sagan Effect?  [Subscription required] Excerpt (with my emphasis): [Sean Carroll] offered 13 pieces of advice…: “Do good research; Make an impact in the field; Bring in grant money… Don’t be too well known outside the field; Don’t write a book; Choose your hobbies wisely.” Carroll argued that academics look askance at colleagues that have too high of a public profile. Not out of envy—but because they worry that public scientists care more about their…

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Hydrogen-atom transfer in DNA base pairs (7)

February 10, 2016
James Kohl
Adaptations, biophotonics, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation
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Perry Marshall says: February 9, 2016 at 9:45 pm James, if you think you have a solution then fill out a proper prize submission and show that you have met the specification. My comment: There is no prize submission form and I repeatedly requested the Non-Disclosure Agreement. I think that Perry Marshall knows I will win the prize, and simply doesn’t want the challenge to his claims that I would provide in my submission.  For example, I would include citations…

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Eibi Nevo gets it wrong

August 15, 2015
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, Variations
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Eibi Nevo: Evolution, Let’s Get It Right, It’s the “Basis of Everything” Excerpt: “The best we can know about origin of life may be from viruses we are looking at. They could have been at the origin of life before they parasitized it, or became symbionts in prokaryotes and eukaryotes. . . .” My comment: Let’s really get it right. Were viruses created first or did they parasitize all creation via perturbation of nutrient-dependent RNA-mediated protein folding in the context…

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The stability of organized genomes (2)

August 5, 2015
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, RNA Directed, Variations
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See also: The stability of organized genomes See also: The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior Excerpt: Despite the high heritability of depression and a clear genetic contribution to the disease, the identification of genetic risk factors for depression has been very difficult. The first published candidate to reach genome-wide significance in depression was SLC6A15, a neuronal amino acid transporter. With a reported 1,42 fold increased risk of suffering from depression associated with a…

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Epimutation.com: a domain of confusion

August 5, 2015
James Kohl
RNA Directed
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See: Epimutation.com Currently, there is no content. When content is added, it will almost undoubtedly further the cause of confusion that evolutionary theorists must use in attempts to prevent serious scientists from Combating Evolution to Fight Disease. Serious scientists use what is currently known about biologically-based cause and effect. Prepare yourself for more pseudoscientific nonsense about epimutations. Until then, see this: Researchers investigate effect of environmental epigenetics on disease and evolution Excerpt 1) …environmental factors are having an underappreciated effect…

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Becoming biologically informed

July 6, 2015
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed
One Comment

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis Abstract excerpt: In this article, we describe various common RNA toxicity pathways, namely epigenetic gene silencing, nucleolar stress, nucleocytoplasmic transport, bi-directional gene transcription, repeat-associated non-ATG translation, RNA foci formation and cellular protein sequestration. Journal article conclusion: Although protein toxicity was considered to play a major role in the pathogenesis of repeat expansion diseases, we now know that mutant transcripts also induce cell dysfunction and death via multiple mechanisms, such as…

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Bees and primates automagically evolve

May 15, 2015
James Kohl
Adaptations, Ecology, Nutrigenomics, Pharmacogenomics, RNA Directed
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The Evolution of Social Bees Excerpt: …one key feature of increased sociality is an elaboration of gene regulation capacity. See also: From Fertilization to Adult Sexual Behavior (1996) Excerpt: …odor perception is more akin to the immune system workings where multitudes of receptors are each uniquely responsive to chemical structures (Bartoshuk and Beauchamp, 1994; Buck and Axel, 1991). Moreover, these receptor proteins are chemically and structurally similar to those that bind neurotransmitters and hormones (Buck and Axel, 1991). See also:…

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