hemoglobin

Predictable idiosyncratic evolved convergence

Predictable convergence in hemoglobin function has unpredictable molecular underpinnings Excerpt: …predictable changes in biochemical phenotype do not have a predictable molecular basis. My comment: Biochemical phenotypes are predicted at every level of examination that starts with hydrogen-atom energy transfer in DNA base pairs in solution, and at least two of these authors know that. See: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin June 14, 2013 Excerpt: Fig. 2 Difference in the network of hydrogen bonds between high- and low-altitude…

Read More

The Mind’s Eyes (revisited)

Author’s copy: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences (2007) Abstract: The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self.  Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response.  The organization and activation of this neuroendocrine response modulates the concurrent maturation of the mammalian neuroendocrine system, the reproductive system, and the central nervous system during the development of sexual preferences that…

Read More

Energy-dependent biodiversity

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Abstract excerpt: …the same activating principles used for decades to make simple C–N (amide) bonds from carboxylic acids with loss of water can be used to make C–C bonds… Conclusion: The ready availability of numerous carboxylic acids (which are easily converted to esters) contributes to the reaction’s versatility. My comment: Light energy-induced chemical reaction versatility links what is known about biophotonics to the physiology of energy-dependent pheromone-controlled reproduction in…

Read More

Bringing RNA back to epigenetics (20 years later)

Has Contemporary Academia Outgrown the Carl Sagan Effect?  [Subscription required] Excerpt (with my emphasis): [Sean Carroll] offered 13 pieces of advice…: “Do good research; Make an impact in the field; Bring in grant money… Don’t be too well known outside the field; Don’t write a book; Choose your hobbies wisely.” Carroll argued that academics look askance at colleagues that have too high of a public profile. Not out of envy—but because they worry that public scientists care more about their…

Read More

Hydrogen-atom transfer in DNA base pairs (7)

Perry Marshall says: February 9, 2016 at 9:45 pm James, if you think you have a solution then fill out a proper prize submission and show that you have met the specification. My comment: There is no prize submission form and I repeatedly requested the Non-Disclosure Agreement. I think that Perry Marshall knows I will win the prize, and simply doesn’t want the challenge to his claims that I would provide in my submission.  For example, I would include citations…

Read More

Eibi Nevo gets it wrong

Eibi Nevo: Evolution, Let’s Get It Right, It’s the “Basis of Everything” Excerpt: “The best we can know about origin of life may be from viruses we are looking at. They could have been at the origin of life before they parasitized it, or became symbionts in prokaryotes and eukaryotes. . . .” My comment: Let’s really get it right. Were viruses created first or did they parasitize all creation via perturbation of nutrient-dependent RNA-mediated protein folding in the context…

Read More

The stability of organized genomes (2)

See also: The stability of organized genomes See also: The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior Excerpt: Despite the high heritability of depression and a clear genetic contribution to the disease, the identification of genetic risk factors for depression has been very difficult. The first published candidate to reach genome-wide significance in depression was SLC6A15, a neuronal amino acid transporter. With a reported 1,42 fold increased risk of suffering from depression associated with a…

Read More

Epimutation.com: a domain of confusion

See: Epimutation.com Currently, there is no content. When content is added, it will almost undoubtedly further the cause of confusion that evolutionary theorists must use in attempts to prevent serious scientists from Combating Evolution to Fight Disease. Serious scientists use what is currently known about biologically-based cause and effect. Prepare yourself for more pseudoscientific nonsense about epimutations. Until then, see this: Researchers investigate effect of environmental epigenetics on disease and evolution Excerpt 1) …environmental factors are having an underappreciated effect…

Read More

Becoming biologically informed

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis Abstract excerpt: In this article, we describe various common RNA toxicity pathways, namely epigenetic gene silencing, nucleolar stress, nucleocytoplasmic transport, bi-directional gene transcription, repeat-associated non-ATG translation, RNA foci formation and cellular protein sequestration. Journal article conclusion: Although protein toxicity was considered to play a major role in the pathogenesis of repeat expansion diseases, we now know that mutant transcripts also induce cell dysfunction and death via multiple mechanisms, such as…

Read More

Bees and primates automagically evolve

The Evolution of Social Bees Excerpt: …one key feature of increased sociality is an elaboration of gene regulation capacity. See also: From Fertilization to Adult Sexual Behavior (1996) Excerpt: …odor perception is more akin to the immune system workings where multitudes of receptors are each uniquely responsive to chemical structures (Bartoshuk and Beauchamp, 1994; Buck and Axel, 1991). Moreover, these receptor proteins are chemically and structurally similar to those that bind neurotransmitters and hormones (Buck and Axel, 1991). See also:…

Read More