HERVs

microRNA-mediated cures (7)

Pharmacogenomics: A road ahead for precision medicine in psychiatry 10/6/21 In this 2017 Precision Medicine Virtual Conference presentation, I linked the National Microbiome Initiative from microbial quorum sensing to the physiology of pheromone-regulated genetic processes of reproduction and endogenous RNA interference (#RNAi) via chromosomal rearrangements in flies from the works of Thomas Hunt Morgan (1910) to sympatric speciation across kingdoms. The chromosomal rearrangements link light-activated carbon fixation to the ATP-dependent creation of RNA and fixation of amino acid substitutions links…

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Naturally attenuated viral endemicity (3)

See first: Naturally attenuated viral endemicity (2) Conclusion: Energy-dependent changes in angstroms to ecosystems must be linked to the functional structure of supercoiled DNA via peptide synthesis at the origin  of life and single nucleotide polymorphisms (SNPs) in microRNAs. See also: Spatiotemporal regulation and roles of reproductive phasiRNAs in plants 11/11/21 …co-suppression was discovered as a pioneer silencing phenomenon of RNA interference (RNAi) in petunia in 1990… President Joe Biden’s scientific advisor, Eric Lander linked the facts about co-suppression and…

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MicroRNA-mediated population control (9)

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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Expert 13 (1)

12 Experts Questioning the Coronavirus Panic 3/19/20 President Donald J. Trump is expert 13 in the context of the fact that differential expression of cell types requires biophysically constrained viral latency. That fact became perfectly clear with the experimental evidence presented in  SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome 12/13/20 The researchers: …investigated the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome, and that transcription of the integrated sequences might account for PCR-positive…

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microRNA-mediated quantum error correction (3)

See: microRNA-mediated quantum error correction (1) On 10/19/20, more than 250 additions to the indexed articles that mention the term ‘microRNA’ appeared after 5 days of what appeared to be a moratorium linked to publication of Thousands of Previously Unknown Phages Discovered in Whole-community Human Gut Metagenomes on 10/14/20. See also: Before Virus, After Virus: A Reckoning 10/15/20 The pandemic has energized us, yes, but it has also provided a necessary dose of humility. It has also been a call…

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Pathology constrains X-linked evolution

Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome Excerpt: “Experimental methods are already able to indicate the interactions between enhancers and genes8, 13, 17, 18, 19 but they are strongly constrained by the tissue and time where and when the interaction takes place. In contrast, evolutionary linkage is independent of the tissue or time of expression of the gene, and is applicable to any sequenced vertebrate genome, as it was done here for human.” My comment: Experimental…

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