honeybee

Pharmacogenomics

“The gene, cell, tissue, organ, organ-system pathway is a neuroscientifically established link between sensory input and behavior. Marts and Resnick (2007) stress the importance of this pathway in the context of a systems biology approach to pharmacogenomics.” (Kohl, 2012) “Naftolin (1981) stressed its importance to the understanding of sex differences. This pathway is sensitive to conditioning. Sensory input from an organism’s environment activates and reactivates the pathway and causes changes in hormone secretion that condition hormone-driven behavior.” (Kohl, 2012) See…

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ALPHA GENOMIX

ALPHA GENOMIX LABORATORIES INC Alpha genomics (for those unfamiliar with their spelling) Re: On this team, Dr. Hani El Shawa, is also first author of Prenatal Ethanol Exposure Disrupts Intraneocortical Circuitry, Cortical Gene Expression, and Behavior in a Mouse Model of FASD. The Journal of Neuroscience, 27 November 2013, 33(48): 18893-18905. Excerpt: “Changes in gene expression reported in this study may be caused by altered DNA methylation, an epigenetic modification that cells use to mediate gene expression (Moore et al.,…

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Color vision refutes the evolutionary dogma of gene duplication

The Rainbow Connection Color vision as we know it resulted from one fortuitous genetic event after another. By Kerry Grens | October 1, 2014 Excerpt 1: “The fact that we have the same few amino-acid substitutions as New World monkeys argues there was a single ancestral variation that gave rise to [the cone opsins of] both Old and New World primates,” Nathans says. “It leads to an interesting twist on the evolutionary dogma of gene duplication.” My comment: The fact…

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Epigenetically-effected metabolic shifts and ecological adaptations

Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, monomethylation of histone H3 at lysine 4, and acetylation of histone H3 at lysine 27. They also analyzed genome-wide transcription and transcription factor binding. Together…

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Probable changes in connectivity

Table of Contents: Nature Reviews Neuroscience October 2014 Vol 15 No 10 Excerpt from: Research Highlights: Learning and memory: Uncoupling memory traces “The emotional valence of a memory can be changed, and this probably involves a change in the connectivity between hippocampal and amygdalar memory traces.” My comment: 1) The connectivity change is epigenetically-effected by olfactory/pheromonal input. 2) Epigenetically-effected RNA-mediated events link the epigenetic landscape to the physical landscape of DNA in species from microbes to man. 3) Conserved molecular…

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Watching and waiting for more retractions

Brain Genetics Paper Retracted A study that identified genes linked to communication between different areas of the brain has been retracted by its authors because of statistical flaws. By Anna Azvolinsky | September 4, 2014 Excerpt: “This retraction raises the issue of how many papers may have falsely reported gene associations because of the constantly evolving changes in gene assemblies and boundaries. That’s really alarming to me.” My comment: I am alarmed by those who report anything in terms of…

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Behavior (3): All responses are RNA-mediated in bees

See: Honey bees as a model for understanding mechanisms of life history transitions. Excerpt: “In this review we discuss the physiological and genetic mechanisms of this behavioral transition, which include large scale changes in hormonal activity, metabolism, flight ability, circadian rhythms, sensory perception and processing, neural architecture, learning ability, memory and gene expression.” My comment: An earlier review by Eleckonich and Robinson (2000) “Organizational and activational effects of hormones on insect behavior” cited our 1996 review of epigenetically-effected organization and activation…

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Ecologically linked adapted ants and brains

Ants Swarm Like Brains Think A neuroscientist studies ant colonies to understand feedback in the brain. By Carrie Arnold April 24, 2014 Excerpt: “The behavior of each individual in the group is set by the rate at which it meets other ants and a set of basic rules. Its behavior alters that of its neighbors, which in turn affects the original ant, in a classic example of feedback. The result is astonishing, complex behavior.” My comment: The molecular mechanisms of…

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The wrong picture of our evolution

“We have built a picture of our evolution based on the morphology of fossils and it was wrong.” I’ve repeatedly cited the latest literature, especially in the context of Skull 5. The article linked below is another clear representation of how the wrong picture of our evolution was built via a series of misrepresentations that ignored biological constraints while theorists touted mutation-initiated natural selection. Why don’t they simply admit that they are wrong, so others can move on? Fifty years…

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Social experiences epigenetically effect gene networks

Networks of Genes Respond to Social Experiences October 13, 2013, from Searching for the Mind with Jon Lieff, M.D. Excerpt 1: “The gene networks of social experience are consistent through many animals.” My comment: Not just many animals; the gene networks of social experiences must be consistent in all animals that adaptively evolved. You cannot get from microbes to man with any consistent model of cause and effect until you realize that the molecular mechanisms that enable cause and effect…

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