hormones

Energy-dependent physical and biophysical constraints (9)

Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells Excerpt 1) The chromatin structure of DNA determines genome compaction and activity in the nucleus. My comment:…

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Energy-dependent physical and biophysical constraints (2)

Summary: The mind does not exist in nature. It is a manifestation of how ecological variation must be linked to the creation of food energy-dependent pheromone-controlled ecological adaptations. Energy-dependent physical and biophysical constraints (1) The energy-dependent de novo creation of all receptors is biophysically constrained. See: Channel opening and gating mechanism in AMPA-subtype glutamate receptors This was reported as: Scientists capture first image of major brain receptor in action Defects in glutamate receptors, or the processes they mediate, are implicated…

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Energy-dependent epigenetic translation to mRNA stability (4)

See first: Energy-dependent epigenetic translation to mRNA stability (3) First-ever direct observation of chiral currents in quantum Hall atomic simulation The report on the simulation fails to address the facts about what happens at the level of hydrogen-atom transfer in DNA base pairs in solution when you have an MRI. Perhaps the link from chirality to autophagy and all cell type differentiation in all living genera is not obvious.   See: Magnetic resonance imaging MRI is based upon the science…

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Cytosis: A Cell Biology Board Game

Cytosis: A Cell Biology Board Game A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses! 3/27/17 My comment: On March 24, 2017 this article was published in ‘Science.’ A conserved NAD+ binding pocket that regulates protein-protein interactions during aging The article linked virus-driven energy theft from hydrogen-atom transfer in DNA base pairs in solution to all pathology. On March 24, 2017 this article also was published in…

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Antithetical conclusions (4)

Evidence for sex-specific genetic architectures across a spectrum of human complex traits …will need to disentangle whether sex genetic heterogeneity may arise as a consequence of interactions with genetic loci located on the sex chromosomes, differences in gene control due to differences in the sex-specific cellular environment, or more general differences in environmental exposures between the sexes. Nutrient energy-dependent pheromone-controlled sex differences in the cell types of species from yeasts to humans link changes in the microRNA/messenger RNA balance and…

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Center stage RNA-mediated events (since 1996)

‘Junk’ DNA now center stage Excerpt: The implications of these findings can be linked to medical conditions from chronic stress to neurodegenerative diseases. Anna Di Cosmo​’s group, Eugene Daev‘s group, and Bruce McEwen‘s group have linked RNA-mediated amino acid substitutions from atoms to ecosystems and all pathology in all living genera. In the early 90’s, Bruce McEwen told me how to validate my model of cell type differentiation by starting with gene activation. In, Effect of two pyrazine-containing chemosignals on…

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Unconscious affect (revisited)

Kohl et al., (2001) …the importance of human non-verbal signals is based upon information processing, which occurs in the limbic system, and without any cognitive (cortical) assessment. Affect thus does not require conscious interpretation of signal content. Underlying this fact is that affect dominates social interaction and it is the major currency in social interactions [6]. Affective reactions can occur without extensive perceptual and cognitive encoding. They are made with greater confidence than cognitive judgments, and can be made sooner…

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Appetite for ingesting theories (raw)

On The Edge of Neuroscience and Psychology Facebook Group, no one seems interested enough to discuss the difference between an epigenetic effect on hormones and an affect of hormones on behavior. Without a starting point for discussion, there may be no further comments on Goy, R. W., and McEwen, B. S. (1980). Sexual Differentiation of the Brain. MIT Press, Cambridge, MA. Without discussion of nutrient-dependent RNA-mediated sexual differentiation of cell types in the brain, there is no way to link…

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Bees and primates automagically evolve

The Evolution of Social Bees Excerpt: …one key feature of increased sociality is an elaboration of gene regulation capacity. See also: From Fertilization to Adult Sexual Behavior (1996) Excerpt: …odor perception is more akin to the immune system workings where multitudes of receptors are each uniquely responsive to chemical structures (Bartoshuk and Beauchamp, 1994; Buck and Axel, 1991). Moreover, these receptor proteins are chemically and structurally similar to those that bind neurotransmitters and hormones (Buck and Axel, 1991). See also:…

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Targeting theories to fight disease

Researchers identify new target for anti-malaria drugs Excerpt with my (emphasis): Ultimately what defines a parasite is that they require certain key nutrients from their host,” he says. “So they have had to evolve ways to get around their own barriers, to gain access to these nutrients. The claim that parasites evolve the ability to gain access to nutrients continues to kill millions of people, which is why serious scientists are Combating Evolution to Fight Disease The link between the…

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