hormones

Viruses and ecologically adapted animals

“I should think we might fairly gauge the future of biological science, centuries ahead by estimating the time it will take to reach a complete comprehensive understanding of odor. It may not seem a profound enough problem to dominate all the life sciences, but it contains, piece by piece, all the mysteries” (p. 732). — Lewis Thomas (1980) Olfaction and odor receptors link what you can read about here or at Perfuming the Mind.com and at Searching for the Mind.com…

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Behavior (4): All responses are RNA-mediated in birds

Bird Genomes Abound Scientists complete the largest-ever comparative genomic study of birds. By Ruth Williams | December 11, 2014 Excerpt: “The results of this effort provide not only the most precise genetic history of birds to date, but also reveal why avian genomes tend to be small compared to those of other vertebrates: because they have lost a lot of genes and have far fewer repeat sequences. Furthermore, the data show that, compared with mammals, both the nucleotide sequences and…

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Chemical ecology and RNA-mediated control of DNA loops

DNA Loop-the-Loops A new full-genome map indicates how DNA is folded within the nuclei of human cells.By Kate Yandell | December 11, 2014 Excerpt: “…many loops were conserved among cell types, and even between mice and humans. But others seemed to drive cell type-specific gene expression patterns.” My comment to The Scientist Magazine: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt: “A form of GnRH associated with sexual orientation in yeasts links control of the feedback loops and developmental processes required for…

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A model of MHC 'evolution'

Sexual selection and the evolutionary dynamics of the major histocompatibility complex Excerpt: “Here, we present the results of the first model of MHC evolution incorporating both survival and reproduction, modelling the combined effects of natural selection and MHC-based disassortative mating on patterns of MHC allelic diversity.” My comment: Results from their first mathematical model can be compared to representations of biologically-based cause and effect in the context of our model. See From Fertilization to Adult Sexual Behavior. We linked RNA-mediated…

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Systems biology and memory disorders

Reversal of cognitive decline: A novel therapeutic program Reported as: Memory loss associated with Alzheimer’s reversed: Small trial succeeds using systems approach to memory disorders News Article Excerpt: (1) eliminating all simple carbohydrates, leading to a weight loss of 20 pounds; (2) eliminating gluten and processed food from her diet, with increased vegetables, fruits, and non-farmed fish; (3) to reduce stress, she began yoga; (4) as a second measure to reduce the stress of her job, she began to meditate…

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Behavior (2): All responses are RNA-mediated not genetically-determined

Diana Maria Petrosanu also asked: “who was the author of the article that had stolen your ideas?“ I cannot recall claiming that anyone had stolen our ideas or my ideas. See: Behavior: The first response is RNA-mediated not genetically-determined. In subsequent published works, I extended what we detailed about the molecular epigenetics of sex differences in cell types from yeasts to mammals via examples from model organisms of RNA-mediated cell type differentiation in different species. That is why I was…

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Targeting a cancer gene

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous masterminds of malignancies.” and see K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions [subscription required] Excerpt: “…initial evaluation of our compounds in lung cancer cell lines suggests allele-specific impairment of K-Ras function.” My comment: 1) They ignored any aspect…

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