human endogenous retroviruses

For God and Country

Energy-dependent structure and function: Until death (5)

Summary: If a player starts with evolution instead of the creation of energy that links ATP to the creation of RNA, the player is a loser. Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull Secular: Ancient Viruses Are Buried in Your DNA (2017) by…

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Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense

Summary: Not only does everything known to serious scientists about energy link RNA synthesis to life, everything McEwen and others have published links nutrient stress and/or social stress to the virus-driven degradation of messenger RNA and all pathology. As moderator of the International Society for Human Ethology (ISHE), a not-for-profit scientific organization that consistently touts pseudoscientific nonsense in the context of neo-Darwinian evolution, Jay R. Feierman’s attacks on the works of serous scientists are increasing in frequency and in magnitude.…

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Epigenetics and autophagy vs mutations and evolution (4)

“Tobacco mosaic virus (TMV) is a positive-sense single stranded RNA virus that infects a wide range of plants, especially tobacco and other members of the family Solanaceae. The infection causes characteristic patterns, such as “mosaic”-like mottling and discoloration on the leaves (hence the name). TMV was the first virus ever to be discovered. Although it was known from the late 19th century that an infectious disease was damaging tobacco crops, it was not until 1930 that the infectious agent was…

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Olfaction & the octopus and human genomes (2)

Darwinian evolution in the light of genomics Eugene Koonin excerpt: The distribution of evolutionary rates across sets of orthologous genes, the distribution of the sizes of paralogous gene families, the negative correlation between the expression level and the sequence evolution rate of a gene, and other relationships between key evolutionary and phenomic variables seem to be genuine universals of evolution. The simplicity of these universal regularities suggests that they are shaped by equally simple, fundamental evolutionary processes, rather than by…

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Is SUMOylation RNA-directed DNA methylation? (revisited)

See: Is SUMOylation RNA-directed DNA methylation? posted here on 6/16/15 See also: 1) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3 (subscription required 6/17/15) 2) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3 (open access 6/23/15) 3) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton (open access 6/23/15) 4) MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream…

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Viruses in gut microbes

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells 5/4/15 Excerpt: Extended Data Figure 3 | Generation of H3.3-isoform-specific antibodies. Related to Fig. 1. a, Schematic of amino acid sequence differences for the canonical histones H3.1 and H3.2 versus the histone variant H3.3. H3.3 differs from H3.2 or H3.1 at only 4 or 5 amino acids, positions 31, 87, 89, 90 and 96, as indicated. My comment: The difference in amino acid substitutions can be linked…

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Pathology constrains X-linked evolution

Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome Excerpt: “Experimental methods are already able to indicate the interactions between enhancers and genes8, 13, 17, 18, 19 but they are strongly constrained by the tissue and time where and when the interaction takes place. In contrast, evolutionary linkage is independent of the tissue or time of expression of the gene, and is applicable to any sequenced vertebrate genome, as it was done here for human.” My comment: Experimental…

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