humans

Virus-driven downsizing of the human brain (5)

Virus-driven downsizing of the human brain (3) (8/9/16) Virus-driven downsizing of the human brain (4) (4/23/17) Who the heck is James V. Kohl? Thanks for asking. Posted by u/Sphinx_for_hire 3 months ago I’m in biochemistry/toxicology and was reading up on LUCA (aka Last Universal Common Ancestor). While Googling the work of Nick Lane, I stumbled upon the following page absolutely flaying Lane’s and others’ LUCA theories. This guy, James V. Kohl, has many websites in which he writes about human…

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MicroRNA-mediated denuclearization (2)

Summary: The virus-driven theft of quantized energy creates a cellular environment that promotes the survival and self-proliferation of viruses by encoding viral miRNAs or miRNA-like molecules. The viral miRNAs or miRNA-like molecules target different types of host cells. The sun’s anti-entropic virucidal energy biophysically constrains viral latency in the context of global control of human ES cell differentiation via circRNAs derived from lncRNAs. That fact refutes all neo-Darwinian gene-centric pseudoscientific nonsense. That fact also attests to the link from Chinese…

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Evolutionary theories of epigenetic drift

Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data My summary: Outside the context of food energy-dependent biophysically constrained pheromone-controlled viral latency, mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. For example, age-differentially-methylated sites across the genome showed significant MA-consistent increases in heritability with age or significant DS-consistent decreases in heritability. Their results supposedly show that both MA and DS play a role in explaining aging and aging-related changes but…

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Proof: Sunlight is energy as information

Hypothesis: Kallmann’s syndrome is proof that virus-driven energy theft causes all pathology in species from archaea to humans via the degradation of messenger RNA and the loss of one allele.   Thought experiment: Step 1) The loss of one allele and the transgenerational epigenetic inheritance of Zika virus-damaged DNA can be compared to the degradation of messenger RNA in bacteria that is manifested in archaea and L-forms. Step 2) The degradation of messenger RNA in primates differentiates healthy longevity from…

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Wikipedia refutes theistic evolution

RNA-Directed DNA Methylation Besides RNA molecules, a plethora of proteins are involved in the establishment of RdDM, like Argonautes, DNA methyltransferases, chromatin remodelling complexes and the plant-specific Polymerase IV and Polymerase V. All these act in concert to add a methyl-group at the 5′ position of cytosines. In contrast to animals, cytosines at all sequence context (CG, CHG, CHH) may get de novo methylated in plants. There is no such thing as de novo methylation. Methylation is energy-dependent. Virus-driven energy…

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Dobzhansky 1973 and precision medicine (3)

Dobzhansky 1973 and precision medicine Dobzhansky 1973 and Precision Medicine (2) How Do Bacteria Help Cancer Studying bacterial effects on cancer are very complex, because there is no one clear mechanism Jon LIeff has again obfuscated the clarity of facts about energy-dependent conserved molecular mechanisms. These are the facts: 1) Closed feedback loops link nutrient energy-dependent pheromone-controlled quorum sensing in bacteria to supercoiled DNA in all living genera. 2) Virus-driven energy theft causes the degradation of messenger RNA in bacteria…

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Epigenetics and autophagy vs mutations and evolution (2)

Plants send light to roots to ‘see’ underground My comment: Sending light requires an energy-dependent link from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organanized genomes from virus-driven energy theft and genomic entropy. See Schrodinger (1944) Excerpt: Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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How did the innate immune system evolve?

Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites Abstract excerpt: Why would a system exist that reduces the vigor of potential mates prior to mating? Addressing this question could provide insights into mechanisms and evolution of sexual conflict and reveal sensory inputs that regulate aging. Highlights excerpt: An unknown signal accelerates larval development, specifically the onset of puberty Reported as: Male chemistry primes females for reproduction—but at a cost “There is a fine balance between reproduction and…

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Plant microRNAs slow virus-driven aging

Six plant extracts delay yeast chronological aging through different signaling pathways The evolutionarily conserved nutrient-sensing signaling pathways that accelerate chronological aging in yeast (Figure 9) are known to stimulate chronological senescence and geroconversion of post-mitotic human cells; these pathways are likely to expedite organismal aging and cancer development in humans [87-93]. There is no experimental evidence of biologically-based cause and effect that starts with the conservation of nutrient-sensing pathways. The nutrient-sensing pathways link the de novo creation of G protein-coupled…

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