humans

Plant microRNAs slow virus-driven aging

Six plant extracts delay yeast chronological aging through different signaling pathways The evolutionarily conserved nutrient-sensing signaling pathways that accelerate chronological aging in yeast (Figure 9) are known to stimulate chronological senescence and geroconversion of post-mitotic human cells; these pathways are likely to expedite organismal aging and cancer development in humans [87-93]. There is no experimental evidence of biologically-based cause and effect that starts with the conservation of nutrient-sensing pathways. The nutrient-sensing pathways link the de novo creation of G protein-coupled…

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Food supplement or licensed immunostimulant?

Glucan from Food Supplement to a Licensed Drug   Excerpt: “…β-glucan possesses a significant immunostimulating activity in a wide variety of species, including earthworms, shrimp, fish, chicken, rats, rabbits, guinea pigs, sheep, pigs, cattle, and, last but not least, humans. Based on these results, it has been concluded that β-glucan represents a type of immunostimulanting molecule that is actively spanning full evolutionary spectrum. Some experiments also show that β-glucan can help even in the protection of plants. β-Glucan is therefore…

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MicroRNAs and sexual orientation

A neural circuit encoding sexual preference in humans Excerpt: We anticipate the identification of a core neural circuit for sexual preferences to be a starting point for further sophisticated investigations into the neural principles of sexual behavior and particularly of its aberrations. My comment: They link sexual orientation in yeasts to humans but fail to recognize the fact that it is nutrient energy-dependent and pheromone-controlled by RNA methylation, the innate immune system, and supercoiled DNA. 20 years after we published…

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Energy dependent RNA-mediated immunity (4)

The Mitochondrial Basis of Aging Excerpt:  …the mutation at amino acid position 257 results in an enzyme that retains normal polymerase function but has impaired proofreading activity. Mice containing one or two copies of this proofreading-deficient POLG accumulate a significant level of mitochondrial mutations, and homozygous knockin mice exhibit an accelerated aging phenotype (Kujoth et al., 2005; Trifunovic et al., 2004). Nonetheless, while this model clearly links mitochondrial mutations to aging, it should be noted that the type and magnitude…

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Bringing RNA back to epigenetics (20 years later)

Has Contemporary Academia Outgrown the Carl Sagan Effect?  [Subscription required] Excerpt (with my emphasis): [Sean Carroll] offered 13 pieces of advice…: “Do good research; Make an impact in the field; Bring in grant money… Don’t be too well known outside the field; Don’t write a book; Choose your hobbies wisely.” Carroll argued that academics look askance at colleagues that have too high of a public profile. Not out of envy—but because they worry that public scientists care more about their…

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Supercoiled DNA constrains virus-driven genomic entropy

1) Genes linked with malaria’s virulence shared by apes, humans and 2) Supercoiled DNA is far more dynamic than the ‘Watson-Crick’ double helix were reported today. One report (1) links viruses to the evolution of biodiversity in chimpanzees and humans compared to gorillas. The other report (2) links nutrient energy-dependent base pair changes to RNA-mediated amino acid substitutions and DNA repair. Both reports are linked to open access publications: See 1)  Ape parasite origins of human malaria virulence genes Excerpt:…

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Eibi Nevo gets it wrong

Eibi Nevo: Evolution, Let’s Get It Right, It’s the “Basis of Everything” Excerpt: “The best we can know about origin of life may be from viruses we are looking at. They could have been at the origin of life before they parasitized it, or became symbionts in prokaryotes and eukaryotes. . . .” My comment: Let’s really get it right. Were viruses created first or did they parasitize all creation via perturbation of nutrient-dependent RNA-mediated protein folding in the context…

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As obvious as the nose on your face

Why would olfactory orientation and navigation be less likely than the RNA-mediated link to sexual orientation in species from yeasts to humans? See: From Fertilization to Adult Sexual Behavior and see: Olfactory Orientation and Navigation in Humans reported as: Humans’ built-in GPS is our 3-D sense of smell Excerpt: We never thought humans could have a good enough sense of smell for this,” said Jacobs. But in retrospect, she noted, the results are “as obvious as the nose on my…

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Rejecting pseudoscientific nonsense

Rejecting Evolutionary Psychology is Rejecting Evolution Discussion on the closed group Applied Evolutionary Psychology includes my comments on several other reports, beginning with: My comments on: Early Code New research points to key properties of transfer RNA molecules and amino acids that may have supported the origin of life on Earth. I wrote: Thanks for providing yet another reason to reject evolutionary psychology.  Acceptance of RNA-mediated links to cell type differentiation in all cells of all individuals of all genera…

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Correctly modeling life on this planet

We cannot conceive of a global external factor that could cause, during this time, parallel evolution of amino acid compositions of proteins in 15 diverse taxa that represent all three domains of life and span a wide range of lifestyles and environments. Thus, currently, the most plausible hypothesis is that we are observing a universal, intrinsic trend that emerged before the last universal common ancestor of all extant organisms. — Jordan et al., (2005) The increase in the number of…

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