humidity

Orchestrated death: Francis S. Collins

MicroRNA-155 and antiviral immune responses 10/8/21 The microRNA, miR-155 regulates both adaptive and innate immune responses. …dysregulated expression of miR-155 can result in virus persistence and disruption of the normal response to viral infections. This collaboration among researchers from Iran, UCLA, and South Africa attests to facts that led Francis S. Collins to resign as NIH director. See first: Collins was the first to plan his escape from prosecution. Watch this blog site as others get thrown under the bus…

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God’s microRNA-mediated Creation of genotypes (8)

See first: God’s microRNA-mediated Creation of genotypes (7) The current issue of Science Magazine supports Trump’s claim via the claims in: Protein-coding repeat polymorphisms strongly shape diverse human phenotypes 9/23/21 The repeat polymorphisms vary with ethnicity, which explains the link from what different human populations eat to the pheromone-regulated genetic processes of reproduction across kingdoms from cyanobacteria to humans. See next: An integrated network analysis approach to identify potential key genes, transcription factors, and microRNAs regulating human hematopoietic stem cell…

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Natural selection for adaptation (1)

My August 12, 2021 tweet made more than 34,000 impressions. That fact was reported on August 18, 2021 after I publicly complained about the delay in making it my “Top Tweet” for the month. My complaint was based on the fact that nearly 126,000 citations to published works mention microRNAs. Each of them attests to facts about natural selection for energy-dependent codon optimality. All intelligent serious scientists know that codon optimality biophysically constrains viral latency and healthy longevity across kingdoms…

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microRNA-mediated replication timing (5)

Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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Pheromones protect us from viruses (6)

The Origin of Species (1859) linked the observations of Charles Darwin from his “conditions of life” to all biodiversity on Earth via the physiology of reproduction in all species. Scientific progress across disciplines has since linked his claims to an effective treatment, protonated RNA interference, for virus-driven pathology. See: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 Our recent neutron crystallographic study of the ligand-free SARS-CoV-2 Mpro provided direct visualization of…

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Impeaching the God of Abraham (10)

sunlight and humidity can weaken the coronavirus — Donald J. Trump 4/23/20 …there’s no medical basis for Trump’s statements about sunlight.  Jonathan Reiner, professor of medicine at The George Washington University Hospital 4/24/20 Former president Trump was absolutely correct. He linked physics and chemistry to molecular biology and healthy longevity via Haplotype-resolved diverse human genomes and integrated analysis of structural variation 2/25/21 Structural variants (SVs) —inversions, deletions, duplications, and insertions ≥50 bp in length—and their breakpoints “…are generally more depleted…

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Impeaching the God of Abraham (1)

2/10/21 Researchers who share the Abrahamic faiths have refuted the pseudoscientific nonsense touted by all atheists. See: microRNA 115, 376 results There are currently 1052 results for microRNA and Israel 2,063 results for microRNA and Iran 2414 results for microRNA and Korea For a historical perspective on what is known to all intelligent serious scientists about biophysically constrained viral latency across kingdoms see the references from: Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1…

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Creationism, Communism and Corruption (1)

The Chinese Communist Party (CCP) consistently failed to address facts that link the National Microbiome Initiative to the Precision Medicine Initiative via what people eat and what is known to all intelligent serious scientists about the microRNA-mediated pheromone-regulated genetic processes of reproduction. See for instance more than 113,000 indexed published works that mention “microRNA.” See for example: Multiple microRNAs regulate tacrolimus metabolism through CYP3A5 12/18/20 MicroRNAs are novel regulators of tacrolimus metabolism and the… …CYP3A5 gene polymorphism accounts for the…

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microRNA-mediated quantum error correction (1)

On 10/19/20, more than 250 additions to the indexed articles that mention the term ‘microRNA’ appeared after 5 days of what appeared to be a moratorium linked to publication of Thousands of Previously Unknown Phages Discovered in Whole-community Human Gut Metagenomes on 10/14/20 The discovery of the unknown phages was reported by senior author, Eugene Koonin. For a historical perspective see: Riding the Evolution Paradigm Shift With Eugene Koonin (2015) The entire evolution of the microbial world and the virus…

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