Huntington’s disease

Autophagy in health and disease (1)

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell…

Read More
Electron cloud superimposed on the yin yang symbol

Enzyme-constrained interethnic biodiversity (5)

Conclusion: The problem with -omics is that biologically uninformed researchers keep throwing more bricks into the brickyard but they fail to use any of the bricks to build a model of anything akin to how the energy-dependent functional structure of supercoiled DNA or its diversity is created. The biologically uninformed pseudoscientists end up creating only a brick yard or building a partially constructed wall that prevents serious scientists from getting to the facts about supercoiled DNA The Structural diversity of…

Read More

Energy-dependent physical and biophysical constraints (2)

Summary: The mind does not exist in nature. It is a manifestation of how ecological variation must be linked to the creation of food energy-dependent pheromone-controlled ecological adaptations. Energy-dependent physical and biophysical constraints (1) The energy-dependent de novo creation of all receptors is biophysically constrained. See: Channel opening and gating mechanism in AMPA-subtype glutamate receptors This was reported as: Scientists capture first image of major brain receptor in action Defects in glutamate receptors, or the processes they mediate, are implicated…

Read More

Models are not theories (3)

Learning to Fly: Decoding Neural Circuits in Drosophila melanogaster Excerpt: Anita enjoyed posters ranging from use of microRNAs to model Huntington’s disease(22) to the making of recombinant probes for synapse labeling (23). She spoke of how researchers at all career stages, ranging from graduate students to Nobel Laureates, were present in one venue to share their insights. My comments: What insights will researchers share after publication of  MicroRNA-encoded behavior in Drosophila and comments about Receptor methylation controls behavior? Since the…

Read More