hydrogen-atom transfer in DNA base pairs in solution

Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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An evolutionary theory killer

Epigenetic inheritance of spatiotemporal regulation (5)

Thanks for the Stress, Dad As embryos, the researchers found that the mouse offspring, which exhibited more anxious behavior than usual, also had lower miRNA levels, as did the sperm of the male offspring upon maturity. The stress-linked degradation of messenger RNA is caused by virus-driven energy theft, which has been linked to all pathology in species from bacteria to humans.  For example: Neutrons identify critical details in bacterial enzyme implicated in gastric cancer Ronning’s team focused on H. pylori’s…

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Environmental selection is natural selection (3)

From algae blooms to cancer or prevention Pristine Blue Waters of Boracay Turn Green Ahead of Closure This happens when people ignore facts about how the creation of light and the naturally occurring fixation of light is linked to all biodiversity on Earth via the physiology of reproduction.   MicroRNA-mediated changes in the fixation of RNA-mediated amino acid substitutions favor replication of viruses in the algae. Changes in the microRNA/messenger RNA balance cause the proliferation of the algae that closed…

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RNA-mediated nutritional psychiatry (2)

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease. Neo-Darwinian theorists dispense with Darwin’s food energy-dependent  “conditions of life.” They link mutations and disease to evolution via mathematical models. They exemplify human idiocy. See for example: Neopterygian phylogeny: the merger assay Reported as: Adaptive radiations in the Mesozoic Bony fishes are the most diverse of all…

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RNA-mediated nutritional psychiatry

Summary: Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth Stop this nonsense about de novo gene birth and you will help to stop the school shootings without more gun control. See my presentation at the 2017 Precision Medicine Virtual Conference (2/15/17) Energy as information and constrained endogenous RNA interference See also: Pat Sweeney et al (3/13/2017) Protein misfolding in neurodegenerative diseases: implications and strategies.  A notable development is the creation of collaborative…

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Polymaths and paradigm shifts: from Asimov to Bear (3)

Polymaths and paradigm shifts: from Asimov to Bear (2) “Teilhardism And The New Religion: A Thorough Analysis of the Teachings of Pierre Teilhard de Chardin”, p.18, TAN Books The evolutionist thesis has become more stringently unthinkable than ever before. — Dr. Wolfgang Smith (2015). A Chat with Information Scientist Pedro Marijuán (2017) I’ve based my informational scheme of the cell on this thinking of “distinction on the adjacent” — where molecular recognition is the essential phenomenon over which biological complexity…

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Polymaths and paradigm shifts: from Asimov to Bear (2)

Polymaths and paradigm shifts: from Asimov to Bear (1) See also: Search results for virus-driven energy theft Summary: The creation of enzymes, such as ATP synthase is energy-dependent. The energy biophysically constrains viral latency via the creation of microRNAs and RNA-mediated amino acid substitutions that differentiate the cell types of all living genera. Modifying Other’s Originality without Quote is an Act of Piracy A writer who does not cite the sources in h/h feature article is committing piracy. Piracy is…

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For God and Country

Kinetically Stable Thermodynamically Activated Cell Metabolism (1)

Excerpt: …via his failure to start from the creation of the sun, Philip Ball makes all aspects of food energy-dependent RNA-mediated error-free DNA repair disappear in his attempt to explain biodiversity, which starts with water. How to Cure Aging – During Your Lifetime? (video) This is a fascinating plea for funding. They seem to know that microRNAs regulate the energy-dependent microRNA/messenger RNA balance in species from plants to humans, but they don’t seem to know that the virus-driven theft of quantized…

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The overwhelming ignorance of sex researchers

Summary: J. Michael Bailey, and others like him, pretend to not know how non-coding variants are epigenetically linked from differences in hydrogen bonds to all energy-dependent biophysically constrained morphological and behavioral phenotypes. Genome-Wide Association Study of Male Sexual Orientation [Energy-dependent changes in biophysically constrained viral latency] We identified several [energy-dependent changes in] SNPs with p < 10−5, including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10−7) and 14 (p = 4.7 × 10−7). The genes nearest to these peaks have functions plausibly relevant to…

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For God and Country

Faith in evolution: Paleontology as a molecular science

Keeping the faith For the last 20 years, Mary Schweitzer, a paleontologist at North Carolina State University in Raleigh, has amassed a wealth of evidence that she’s isolated protein fragments from dinosaurs as much as 80 million years old. That bucks the conventional wisdom among paleontologists who argue that proteins, which are made of chains of amino acids, can’t survive more than 1 million years or so. So far, no group other than Schweitzer and her collaborators has managed to…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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