hydrogen-atom transfer in DNA base pairs in solution

Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (2)

October 10, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: The virus-driven degradation of messenger RNA is clearly linked to frontotemporal dementia (FTD) by altered language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment. The social and economic burden of frontotemporal degeneration Reported as: Study reveals staggering economic burden of dementia in younger people Frontotemporal degeneration (FTD) accounts for 20 to…

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Criticisms of a validated model

October 4, 2017
James Kohl
base editing, RNA Directed, RNA editing, RNA-directed DNA methylation
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Microglia Turnover in the Human Brain “With electron microscopy, we find a variety of immune cells in the brain, especially in contexts of disease,” she writes. Richard Feynman predicted this in the context of a lecture on nanotechnology. He presciently placed cryo-EM into the context of a lecture about Plenty of Room at the Bottom. Examination at this level of observable energy-dependent top-down causation has since linked the sun’s anti-entropic virucidal energy from hydrogen-atom transfer in DNA base pairs in…

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Predicting who wins the 2017 Nobel Prizes (4)

October 3, 2017
James Kohl
Adaptations, Autophagy, biophotonics, Ecology, Light Energy, Physics, RNA Directed, Subatomic, Variations
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As you wait to learn who won the 2017 Nobel Prize in Physics and in Chemistry, please consider how these recent reports will be linked from electrons to ecosystems. Every aspect must start with the creation of energy, which must link chemistry to biophysically constrained biologically based life on Earth in the context of the physiology of pheromone-controlled reproduction and Schrodinger’s claims in “What is Life? (1944). Without mention of the anti-entropic virucidal energy of sunlight, the theories of physicists…

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Sexual communication signals: New Insights!

August 31, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Subatomic
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Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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God vs host-derived creation of virus-driven pathology

August 23, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Summary: The virus-driven theft of quantized energy forces cells to compete for nutrient energy-dependent RNA-mediated reprogramming in the context of the structure of photons, one-carbon metabolism, autophagy, and the physiology of reproduction, which links energy-dependent changes in chirality from base pairs to RNA-mediated amino acid substitutions. Host-derived viral transporter protein for nitrogen uptake in infected marine phytoplankton (with my emphasis) Viruses often carry genes acquired from their host. In the present work, we show that a virus of a marine…

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Your indifference is killing you and others

August 16, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
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Summary: Coherence-inducing mechanisms is double-speak for mechanisms that are nutrient-dependent and pheromone-controlled. Feedback loops link odor and pheromone signaling with reproduction has been presented in double-speak as Looplessness in networks is linked to trophic coherence We are currently studying the entropy of the coherence ensemble we defined for this work. “In general, higher trophic coherence would be associated with lower entropy states, which means that if networks are more coherent than the random expectation there must indeed be some kind…

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Energy-dependent physical and biophysical constraints (5)

July 26, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
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Summary: Emmy Noethe’s theorems were developed in the early 1900’s. Richard Feynman inadvertently or purposefully alluded to them as examples of human idiocy. Discover Magazine resurrected the examples of human idiocy in a 2017 article. For comparison, Choi et al., (2017) support the claims that intercellular and interkingdom communication is energy-dependent and controlled by the metabolism of food energy to pheromones. It is obvious that pheromones biophysically constrain the virus-driven degradation of messenger RNA. That fact links everything currently known…

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The emergence of light as energy from a life-giving star

June 20, 2017
James Kohl
Adaptations, base editing, biophotonics, Ecology, Light Energy, Model Organisms, Physics, RNA editing, Variations
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The Sun – our steady, reliable companion – tells a very different story up close “…a mesmerising, perspective-shaking glimpse at Earth’s life-giving star.” (video) Questions: 1) Did the energy in this life-giving star create itself? 2) How is hydrogen-atom transfer in DNA base pairs in solution biophysically constrained. 3) Who created the feedback loops that link the solar analemma from the time-space continuum to representations of biophysically constrained life and free will in the Mobius strip. 4) Was Linda Buck…

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God’s shrinking role in salvation (3)

June 16, 2017
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Summary: I believe there is a bipartisan trend that links conservative Republicans to survival of the species, but I don’t know for sure what will happen to the liberal Democrats. And, I can’t prove it!   Helicity and chirality https://www.facebook.com/ed.unverricht/videos/10155506720828729/ See also: God’s shrinking role in salvation (2) A Theory of Reality as More Than the Sum of Its Parts “Causal emergence is a way of claiming that your agent description is really real,” said Hoel, a postdoctoral researcher at…

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Energy-dependent epigenetic translation to mRNA stability (6)

May 22, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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See: Energy-dependent epigenetic translation to mRNA stability (5) Five energy-dependent amino acid substitutions are linked to differences in RNA content and biodiversity in 4 mammalian species. Excerpt: Species- and tissue-specific variation in mt-tRNA incorporation into the mt-LSU was analyzed….  Analysis of porcine dermal fibroblasts (C), human osteosarcoma 143B cells (D), bovine cardiac tissue (E), and rat hepatic tissue (F) depicts the relative abundance of each mt-tRNA across fractions (ImageQuant software); represented as a percentage of the total signal. In my…

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