hydrogen-atom transfer in DNA base pairs in solution

Light energy-induced base pair changes (1)

Semisynthetic organisms and synthetic biology Unintended Consequences of Expanding the Genetic Alphabet Conclusion: …phototoxicity results presented herein using a human skin cancer cell line are intended to create awareness to the scientific community of the potential unintended consequences of expanding the genetic alphabet with unnatural nucleosides like those used in this work. Reported as:  Unintended consequences of creating the world’s first semisynthetic organism Excerpt: …the artificial base pair makes living cells more susceptible to damage from low doses of sunlight and…

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Displays of ecological adaptation (2)

On 9/12/16 Philip Qua wrote I have not verified that all of his papers are peer review, but I do believe that some of them are. It is going to take some time and reading of James Kohl papers before I am even willing to venture whether they have merit or not. But on a first glance basis, what I think James is positing here is the causal-effect that drives evolution is more an energy based availability than a random…

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Displays of ecological adaptation

A cinematic approach to drug resistance In a creative stroke inspired by Hollywood wizardry, scientists have designed a simple way to observe how bacteria move as they become impervious to drugs. The experiments are thought to provide the first large-scale glimpse of the maneuvers of bacteria as they encounter increasingly higher doses of antibiotics and adapt to survive—and thrive—in them. My comment: The nutrient-dependent pheromone-controlled ecological adaptations were reported as if mutation-driven evolution of bacteria had occurred. See for comparison:…

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Virus-driven energy theft causes cancer

Three in four don’t know obesity causes cancer Excerpt: As well as general ignorance about obesity and cancer, the survey showed that more than three-quarters (78 per cent) of those asked didn’t know obesity was linked specifically to ovarian cancer. I’ve repeatedly been criticized for use of terms link biologically uninformed and/or science idiots – people who refuse to inform themselves by learning about biologically-based cause and effect. I am surprised when anyone else refers to the “general ignorance.” It’s…

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Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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Increased soil pH and nutrient availability

The work found that this disposal and stockpiling of shells, as well as the people’s use of fire, altered the forest through increased soil pH and important nutrients, and also improved soil drainage. The study appears in Nature Communications. It was reported as: People enhanced the environment, not degraded it, over past 13,000 years 1) Fishing of intertidal shellfish intensified in the area over the past 6,000 years, resulting in the accumulation of deep shell middens, in some cases more…

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Antithetical conclusions (7)

Streamlining the E.coli Genetic Code Once the E. coli genome is pared down to 57 codons, the seven blank codons can be reintegrated and used to introduce nonstandard amino acids, the researchers have proposed; this would open the door to creating a wider range of proteins for industrial applications. A recoded genome also imparts resistance to viral infection and can be used for biocontainment: the DNA incorporated from wild-type E. coli or viruses can’t be used to build proteins successfully…

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Energy-dependent natural fluorescence and bioluminescence

Researchers discover that DNA naturally fluoresces Everybody has overlooked this effect because nobody asked the right question,” said Backman…. “It sounds cliché, but you get the answer to the question you ask. When we actually asked the right question, we got a very different answer than expected. Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Researchers did not ask any questions about how the energy-dependent weekend resurrection of the bacterial flagellum occurred in an organism that…

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The end of neo-Darwinism

Rapid bacterial infection test reduces antibiotic use Excerpt: The rapid tests detect C-reactive protein (CRP), a marker of infections caused by bacteria, in patients’ blood. A low level of CRP is suggestive of viral infection and therefore antibiotic treatment is not required. My comment: The level of one protein differentiates between a viral and a bacterial infection. That fact attests to claims that one RNA-mediated amino acid substitution in a virus increases its virulence. The major antigenic changes of the…

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The tipping point? 50,000 publications (5)

For review see my blog posts “The tipping point? 50,000 publications” with follow-ups: (2) (3) & (4). There are now more than 52,000 published works that link microRNAs to cell type differentiation in the context of healthy longevity or virus-driven energy theft, which has been linked from viral latency to all pathology. At the rate of ~1000 more publications per month that link energy-dependent changes in the microRNA/messenger RNA balance to healthy longevity or link virus-driven energy theft to all…

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