hydrogen-atom transfer in DNA base pairs in solution

Energy-dependent creation and entropy

Theorists tend to use the term de novo when they don’t know. If they don’t know how energy-dependent structures and functions are created, functional structures are created de novo. See for example:  Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection If theorists don’t know what causes mutations, the mutations are de novo mutations. See for example: Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures My comment: The…

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MicroRNAs and/or QTLs: Who buried what?

Making precision medicine a reality: Genomics researchers unveil road map to disease origin Excerpt: This study highlights the significance of mechanistic similarities for uncovering additional interacting downstream effectors of intergenic SNPs… My comment: Use of the term QTL may limit the understanding of how energy-dependent cell type differentiation occurs and how virus-driven energy theft is linked to all pathology. It would be great if someone would explain the difference between what QTLs do and what microRNA flanking sequences  do in…

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Molecular Diagnostics: What is unprotected life (4)

Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions Excerpt: Nature has developed a vast array of voltage-responsive proteins. To improve our ability to optimize the voltage sensitivity, kinetics, and signal size of GEVIs, an in silico search strategy was developed to identify potential voltage-sensing proteins since new genomes are routinely being sequenced. The use of a conserved amino acid motif in the second transmembrane segment of the voltage-sensing phosphatase…

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Molecular Diagnostics: What is unprotected life (3)

Researchers use sunlight to produce chemicals and energy Excerpt: “It has always been right beneath our noses, and yet no one has ever taken note: Photosynthesis by way of the sun doesn’t just allow things to grow; the same principles can be applied to break plant matter down, allowing the release of chemical substances. In other words, direct sunlight drives chemical processes. The immense energy in solar light can be used so that processes can take place without additional energy…

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Molecular Diagnostics: What is unprotected life? (2)

See also: Molecular Diagnostics: What is unprotected life? What is life when it is not protected from virus driven entropy Published on 30 Mar 2016. Presentated at Molecular Diagnostics on April 6 and 7, 2016 The poster also is available at Figshare POSTER (abstract) “The anti-entropic force of virucidal ultraviolet (UV) light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from…

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Molecular Diagnostics: What is unprotected life?

Facile Recoding of Selenocysteine in Nature Abstract excerpt: This illustrates the ease by which the genetic code may evolve new coding schemes, possibly aiding organisms to adapt to changing environments, and show the genetic code is much more flexible than previously thought. My comment: It also refutes the ridiculous theories of neo-Darwinists, by placing ecological variation and ecological adaptation into the context of how nutrient-dependent RNA-mediated events are linked from the innate immune system to the physiology of reproduction and…

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Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Ricki Lewis’ Time Machine (3)

See also: Ricki Lewis’ Time Machine Ricki Lewis Time Machine (2) DNA video in real time. Show the amazing process of DNA transcription using amino acids to turn genes into proteins. My comment: The amino acids are nutrient-dependent and linked to supercoiled DNA by energy-dependent changes in the innate immune system. The innate immune system links metabolic networks and genetic networks to supercoiled DNA. The fact that the amino acid substitutions link the innate immune system to all biodiversity in…

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Creating nutrient-dependent life with enough genes to survive

Design and synthesis of a minimal bacterial genome Excerpt: Cells are the fundamental units of life. The genome sequence of a cell may be thought of as its operating system. It carries the code that specifies all of the genetic functions of the cell, which in turn determine the cellular chemistry, structure, replication, and other characteristics. Each genome contains instructions for universal functions that are common to all forms of life, as well as instructions that are specific to the…

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Virus-driven disorder prevention and health promotion

The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion Excerpt: Evidence has also been growing about the role of epigenetic modification in response to the social environment. My comment: Unexpectedly, Szyf et al., (2016) fail to mention all the evidence of epigenetically-effected RNA-mediated cause and effect that has accumulated since we published our 1996 Hormones and Behavior review. That may explain why they also failed to link energy-dependent hydrogen-atom…

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