hydrogen bonds

RNA-mediated nutritional psychiatry (2)

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition The amino acid optimality code (Fig 6) provides an alternative perspective on sequence changes between paralogs in evolution and human disease. Neo-Darwinian theorists dispense with Darwin’s food energy-dependent  “conditions of life.” They link mutations and disease to evolution via mathematical models. They exemplify human idiocy. See for example: Neopterygian phylogeny: the merger assay Reported as: Adaptive radiations in the Mesozoic Bony fishes are the most diverse of all…

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RNA-mediated nutritional psychiatry

Summary: Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth Stop this nonsense about de novo gene birth and you will help to stop the school shootings without more gun control. See my presentation at the 2017 Precision Medicine Virtual Conference (2/15/17) Energy as information and constrained endogenous RNA interference See also: Pat Sweeney et al (3/13/2017) Protein misfolding in neurodegenerative diseases: implications and strategies.  A notable development is the creation of collaborative…

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Epitranscriptomics: a “new” field

Conclusion: Serious scientists have a 20 year history of their ability to link energy-dependent changes from electrons to ecosystems via the physiology of pheromone-controlled reproduction in the context of hydrogen-atom transfer in DNA base pairs in solution. This fact links hydrogen-atom transfer in DNA base pairs in solution to the fixation of RNA-mediated amino acid substitutions in hydrophobic supercoiled DNA, which protects all organized genomes from virus-driven entropy. I reiterate: Hordenine lacks a meta-hydroxyl group compared to dopamine, rendering it…

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From Precis to Proof in 6000 years

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

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Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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