immunity

Defeating disease and Communism (3)

March 12, 2021
James Kohl
Adaptations, Alternative Splicings, base editing, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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More than 117,000 published works that mention ‘microRNA‘ can be linked from: Playing games with quantum interference 3/10/21 via MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 to the game for ages 14+ Genotype. Everything known to intelligent serious scientists has been linked to Thomas Hunt Morgan’s claims about chromosomal rearrangements and sympatric speciation in flies and other insects. See also: Hypoxia associated multi-omics molecular landscape of tumor tissue…

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The tipping point (revisited): 74,000 publications

June 12, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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President Trump and Kim Jong Un will probably discuss this fact: All serious scientists have learned that quantized energy-dependent microRNA biogenesis links everything known about the creation of sunlight from the physiology of food energy-dependent pheromone-controlled reproduction to viral latency and healthy longevity in the context of the creation of the innate immune system of bacteria. See also: The tipping point (revisited): 73,000 publications May 16, 2018 In less than one month, nearly 1000 publications have been added to the…

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BiondVax Universal Flu Vaccine Patent

January 31, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: …the dream to create an effective universal flu vaccine to ultimately eradicate the flu is placed into the context of claims about changes to the virus. The changes are energy-dependent ecological adaptations. No one claims that the virus mutates or that it evolves. Only biologically uninformed theorists make such ridiculous claims. BiondVax Universal Flu Vaccine Patent Granted in India The patent describes influenza vaccines comprised of multiple copies of several epitopes, such as M-001 which contains nine common and…

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Food for thought: Penrose v Ellis (1)

March 17, 2017
James Kohl
Adaptations, Ecology, Model Organisms, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression
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Food for thought.   The most popular ideas of atheists may still include hypothetical biogenic features that arrived from outer space. That’s how pseudoscientific nonsense appears to become a fact of life on Earth.   All experimental evidence of energy-dependent biologically-based cause and effect must be suppressed or ignored, and that’s what atheists prefer to do. See for instance: Hypothetical biogenic features in the context of the Alan Hills fossil. (Thanks to John Hewitt for reminding me of this.) On…

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Energy-dependent purifying selection / autophagy (5)

November 21, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, Variations
One Comment

See: Energy-dependent purifying selection / autophagy (4) See also: Team develops method to better identify genes involved in diseases If we can pinpoint the genetic mutations that cause a particular disease, we can associate those mutations with specific proteins, and then design drugs to block or activate those proteins. We can also measure the activity of proteins identified in this manner to diagnose diseases more accurately, which is a major goal of precision medicine. In: Histone Acetylome-wide Association Study of…

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Base pairs, olfaction and RNA thermometers

September 22, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Model vs theory: Progress report!

June 14, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

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Ricki Lewis’ Time Machine

January 22, 2016
James Kohl
Adaptations, biophotonics, Ecology, Human Pheromones, Light Energy, Model Organisms, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Can a Quirky Chromosome Create a Second Human Species? Excerpt 1) The first departure from the common house mouse (Mus musculus) was the “tobacco mouse” (Mus poschiavinus), described in 1869 from specimens trapped in a tobacco factory in Valle di Poschiavo, Switzerland. They had big heads and small, dark bodies. Excerpt 2) I spoke to Bear back in 2004, again for The Scientist (a mechanism for the rapid extinction of a dedicated freelance writer is a change in editor-in-chief). Greg Bear is…

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Teleophobes vs teleophiles: a recent history

January 13, 2016
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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  Teleology is a reason or explanation for something in function of its end, purpose, or goal. The teleological or physico-theological argument, also known as the argument from design, or intelligent design argument is an argument for the existence of God or, more generally, for an intelligent creator “based on perceived evidence of deliberate design in the natural or physical world” My comment: Teleophobes make weak arguments peppered with logical fallacies.  They do not make physico-theological arguments, which can be supported…

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Amino acid substitutions, stress, and human behavior

January 7, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity Excerpt: …33% of the human population present a BDNF Val66Met SNP that leads to a valine-to-methionine substitution in the BDNF protein at codon 66, and this SNP has been associated with increased susceptibility to development of stress-related disorders (21, 22). Reported as: Newly discovered windows of brain plasticity may help with treatment of stress-related disorders Excerpt: The researchers also identified the molecule regulating…

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