insects

Evolutionary theories of epigenetic drift

Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data My summary: Outside the context of food energy-dependent biophysically constrained pheromone-controlled viral latency, mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. For example, age-differentially-methylated sites across the genome showed significant MA-consistent increases in heritability with age or significant DS-consistent decreases in heritability. Their results supposedly show that both MA and DS play a role in explaining aging and aging-related changes but…

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Sexual communication signals: New Insights!

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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Food energy-dependent epigenetic adaptation

Mechanism of transmembrane signaling by sensor histidine kinases, was reported as Scientists investigate how the sense of smell works in bacteria …the signaling and inactive states differ only very slightly at the nitrate-binding site – by 0.5-1 angstroms, which is approximately one fifth of the size of the ion itself (1 angstrom is 10-10 meters). However, when this ion binds to the sensor, it causes huge changes in the protein: The helices of different monomers begin to move in different…

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Science journalists or paid propagandists? (4)

See first: Dobzhansky 1973 and precision medicine Prognostic value of the MicroRNA-29 family in multiple human cancers: A meta-analysis and systematic review   ….low expression of miR-29 is associated with aggressiveness and poor prognosis of malignant neoplasms. More importantly, miR-29 might serve as a key biomarker for predicting the recurrence and progression of human cancers. Feeding on the Unseen: Ingestion and Assimilation of Bacteriophages by Brachionus plicatilis (Rotifera) ATP Production Increases with Addition of Varying Concentrations of Vespa Amino Acid Mixture…

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DNA repair via junk DNA (1)

Initiating DNA repair To communicate stress signals within cells, JNKs add phosphate groups to proteins, and the Rochester study found the amino acid residue on SIRT6 that is modified by JNK. They found an energy-dependent RNA-mediated amino acid substitution linked to the physiology of reproduction. It makes DNA repair and transgenerational epigentic inheritance of biologically-based cause and effect possible. The innate immune system, links RNA-mediated amino acid substitutions to supercoiled DNA and protection of organized genomes from virus-driven entropy. The…

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2 genes in 2 species (too expensive and too insignificant)

Characterisation of two Neurogenin genes from the brook lamprey Lampetra planeri and their expression in the lamprey nervous system by Ricardo Lara Ramirez et al. Abstract excerpt: “Here we report the isolation of two Neurogenin genes, LpNgnA and LpNgnB, from the lamprey Lampetra planeri. Phylogenetic analyses show both genes have orthologues in other lamprey species and in a hagfish.” My comment: “…the identity of a single functional GPH [glycoprotein hormone] of the hagfish, hagfish GTH, provides critical evidence for the…

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Quantum correlations/pseudoscience

A quantum advantage for inferring causal structure Preprint excerpt: “The causal inference schemes described here promise extensive applications in experiments exhibiting quantum eff ects. For instance, they can provide a test of whether the dynamics of a given open quantum system is Markovian or not [17{24]. This is because in a non-Markovian evolution, the environment acts as a common cause between the dynamical system at one time and the same system at a later time. Our inference schemes may also help…

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Anti-entropic solar energy

“We have a group trying to model the mitochondrion” — Ulla Mattfolk Trash pickup problem Excerpt: “The PGAM5 protein would be regulated by an allosteric mechanism, in which its biological function would switch from activation of the PINK1/PARKIN pathway for removal of damaged mitochondria to the FUNDC1 pathway for removal of damaged mitochondria,” according to Hannink. “Peptides behave like drug molecules; any time you can identify a biological process that is regulated by a peptide, that peptide becomes a leading…

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Walk towards the light

Cockroaches Accumulate Light to See in the Dark Excerpt: “Taking into account the size of the experiment’s stripes, the optical properties of the roaches’ eyes and the amount of photons available, the team concluded that the roach nervous system pools information from its thousands of photoreceptors over time—in effect, accumulating electrical neural signals and using the summation of those signals to see.” My comment: If there were no link from light-induced amino acid substitutions to nutrient-dependent cell type differentiation in…

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Quantum Superpositions: let there be light

Ideal Negative Measurements in Quantum Walks Disprove Theories Based on Classical Trajectories Reported as: Atoms can be in two places at the same time Excerpt: “This is not yet a proof that quantum mechanics hold for large objects,” cautions Alberti. My comment: I framed my comments and a question in the context of this article on physics. Their claim of a possible size limit on quantum superpositions seemed to divorce top-down causation from cell–cell communication in mammals. That suggested there…

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