Sudden death indel polymorphism

An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations. …different alleles of rs10692285 could alter the local structure of RYR2 mRNA and microRNA (miRNA) binding. See for comparison: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant The differences between the 370A knockin mouse phenotypes and those of loss- and gain-of-function models emphasize the advantage of a more accurate mouse model. In this study an adaptive variant links the mouse…

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Virus-driven mutation or amino acid substitution

A computer program just ranked the most influential brain scientists of the modern era Excerpt: “My first thought was, ‘Who could I tell without appearing immodest?’” he said. “I then realized the only people who would want to hear about this are my children!” My comment: Oxytocin-related peptides are 9-13 amino acids long, but they can be recognized in genomic sequences. That allows them to be placed into the context of claims that link the nutrient energy-dependent de novo creation…

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Biophotonics, glycobiology, quantized biodiversity (2)

From Fertilization to Adult Sexual Behavior (1996) In our section on Molecular epigenetics, we wrote: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility…

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Energy-dependent RNA methylation (8)

Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach Mutation Monte Carlo method (MMC): Excerpt: The mutation moves change the bp sequence but keep the DNA configuration fixed. Both moves change the energy, Eq (1), of the two bp steps involved. My comment: Moves that change energy cost energy. Attributing energy-dependent changes in base pairs to mutations without linking them to the source of the energy change is a neo-Darwinian trick. Nucleosome-amino acid correlation analysis: Excerpt: This produces occurrence probabilities…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]