intercellular

Anti-entropic solar energy

“We have a group trying to model the mitochondrion” — Ulla Mattfolk Trash pickup problem Excerpt: “The PGAM5 protein would be regulated by an allosteric mechanism, in which its biological function would switch from activation of the PINK1/PARKIN pathway for removal of damaged mitochondria to the FUNDC1 pathway for removal of damaged mitochondria,” according to Anti-entropic solar energy

Physics, Chemistry, and Molecular biology (PCMb)

Physics, Chemistry, and Molecular biology (PCMb) link ecological variation to ecological adaptations via a model of gene-cell-tissue-organ-organ system complexity that I first presented in 1992. After adding gene activation by pheromones, I co-authored a book that linked the pheromone-controlled physiology of reproduction across species from microbes to man: The Scent of Eros: Mysteries of Odor Physics, Chemistry, and Molecular biology (PCMb)

Targeting a cancer gene

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous masterminds of malignancies.” and see K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions [subscription Targeting a cancer gene