Jon Lieff

Energy-dependent physical and biophysical constraints (2)

Summary: The mind does not exist in nature. It is a manifestation of how ecological variation must be linked to the creation of food energy-dependent pheromone-controlled ecological adaptations. Energy-dependent physical and biophysical constraints (1) The energy-dependent de novo creation of all receptors is biophysically constrained. See: Channel opening and gating mechanism in AMPA-subtype glutamate receptors This was reported as: Scientists capture first image of major brain receptor in action Defects in glutamate receptors, or the processes they mediate, are implicated…

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From E. coli to monkeys and mankind: Theories vs models (4)

From E. coli to monkeys and mankind: Theories vs models (3)  More Complexity with Tau Tagging and un tagging occurs at Ser214, Thr231 and Ser262 at least in order to attach to microtubules in good neurons along the axon highways. Interactions of these affect the PSD as well such as Ser212/Thr214, Ser202/Thr205, and Thr231 by altering the tau interaction with the PSD. Tau is called a “microtubule associated protein”, one of many stabilizing and regulating the vast amount of shapes…

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Autophagy and health or virus-driven pathology

MiR-142-3p Overexpression Increases Chemo-Sensitivity of NSCLC by Inhibiting HMGB1-Mediated Autophagy Conclusion: HMGB1 is involved in major DNA repair pathways and regulates cell death and survival [27]. Xiao and coworkers have reported that miR-142-3p directly targets HMGB1 to inhibit NSCLC cell proliferation and induce cell apoptosis [18], but the underlying mechanisms have not been elaborated. Our findings suggest that the in vitro anti-NSCLC properties of miR-142-3p reported by Xiao et al. could be at least partially mediated by downregulation of HMGB1-mediated…

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Mitochondria do not adapt

Mitochondria Help Cancers Grow Mitochondria adapt by producing cycles whereby electrons are removed from carbon at a greater rate as food is oxidized to make molecules for the cancers. Mitochondria do not ‘produce’ the ‘cycles’ that link ‘food’ from one carbon metabolism to healthy longevity. Mitochondria do not ‘adapt.’ The food enables thermodynamic cycles of nutrient energy-dependent protein biosynthesis and degradation. Jon Lieff’s “doublespeak” obscures, disguises, distorts, or reverses the meaning of words. See also his section about: Altering Amino…

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Energy-dependent oscillating gene networks organize life

Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the context of evolution. Like all pseudoscientists, he starts with energy but fails to mention where the energy came from or where it goes when virus-driven…

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Politicized science: The demise of RNA-mediated.com?

A post-Presidential election change indicates that politicized science in the USA may be the cause of the steady decline in the number of pages read on this domain. The decline is paired with an increased bounce rate each time I post anything that pits the science of creation against the pseudoscientific nonsense of neo-Darwinian theories. If this domain were used in the context of a social science experiment, the statistics would show that ridiculous theories have left the USA relatively…

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Hypothesis free pseudoscience vs facts (4)

See first Hypothesis free pseudoscience vs facts (3) See also: The terrorist inside my husband’s brain Conclusion: I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen. If only…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Energy-dependent RNA methylation (7)

“…viral latency is responsible for life-long pathogenesis and mortality risk…” – Lieberman (2016) My comment: Energy-dependent RNA-mediated amino acid substitutions are responsible for life-long healthy longevity and decreased mortality risk. See for comparison: How cancer was created by evolution Excerpt 1) But even though it is evolutionary processes that have made cancer such a problem, it is also evolutionary thinking that is now leading to pioneering treatments that could stack the odds against cancer and in favour of our health.…

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Energy-dependent RNA methylation (3)

I wrote: Stop trying to claim anything about energy-dependent cause and effect on any other site including your own. You betrayed my trust in you. I do not take that lightly. On 6/4/16, Tomi Aalto replied: “You don’t own the knowledge.” My comment: Researchers own nothing without patents based on the knowledge. They do not own the knowledge that leads others to learn more about what has been accurately portrayed in the context of biophysically constrained biologically-based cause and effect.…

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