Larry Young

Ecological adaptation: a new definition of heredity (4)

Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity (2018) Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. The restructuring during metamorphosis is biophysically constrained by feedback loops that link olfaction from food odors and pheromones to the creation of enzymes in bacteria and the secretion of the vertebrate decapeptide hormone GnRH (gonadotropin releasing hormone). See: Gonadotropin-releasing hormone agonist binding in…

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Energy-dependent physical and biophysical constraints (5)

Summary: Emmy Noethe’s theorems were developed in the early 1900’s. Richard Feynman inadvertently or purposefully alluded to them as examples of human idiocy. Discover Magazine resurrected the examples of human idiocy in a 2017 article. For comparison, Choi et al., (2017) support the claims that intercellular and interkingdom communication is energy-dependent and controlled by the metabolism of food energy to pheromones. It is obvious that pheromones biophysically constrain the virus-driven degradation of messenger RNA. That fact links everything currently known…

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Antithetical conclusions (4)

Evidence for sex-specific genetic architectures across a spectrum of human complex traits …will need to disentangle whether sex genetic heterogeneity may arise as a consequence of interactions with genetic loci located on the sex chromosomes, differences in gene control due to differences in the sex-specific cellular environment, or more general differences in environmental exposures between the sexes. Nutrient energy-dependent pheromone-controlled sex differences in the cell types of species from yeasts to humans link changes in the microRNA/messenger RNA balance and…

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Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Mystery machine vs model (3)

See Mystery machine vs model (2) Response of mammalian macrophages to challenge with the Chlorovirus ATCV-1. Excerpt: IMPORTANCE:   Virus infections that persist in and stimulate inflammatory factors from macrophages contribute to pathologies in humans. A previous study showed that DNA sequences homologous to Chlorovirus ATCV-1 were found in a significant fraction of oropharyngeal samples from a healthy human cohort. We show here unexpectedly that ATCV-1, whose only known host is an eukaryotic green alga (Chlorella heliozoae) that is an…

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Natural selection: an anti-entropic force?

The second law of thermodynamics is the first law of psychology: evolutionary developmental psychology and the theory of tandem, coordinated inheritances: comment on Lickliter and Honeycutt (2003). This link opens the pdf Excerpt 1) Over the individual life span, what causes organisms to start out as single cells and then anti-entropically climb to dizzyingly greater heights of order (in the case of humans, to cell populations in the trillions built into intricate intercellular structures such as the eye, vasculature, and…

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Viruses, amino acids, and somatic cell types

Although the ultimate origins of RNA viruses are uncertain, it seems reasonable to assume that these infectious agents have a long evolutionary history, appearing with, or perhaps before, the first cellular life-forms (38). The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… Perhaps the evolutionists have placed the cart before the horse on this issue, as proposed by several…

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RNA-mediated terms of virus-induced en-deer-ment

  KarmaWarrior Level – Oh Deer Posted by Stanton Warriors on Friday, August 1, 2014 My comment: This reminds me of a reported incident from: Gibbons, D.L. (1989) Unusual case: Sex in the woods. Medical Aspects of Human Sexuality, 23,10(Oct):63.“Cindy, who was menstruating… had gone alone to a portable commode hidden in a thicket to change her tampon, unaware that a young stag was nearby… Smelling her menstrual secretions, the deer became sexually aroused. He bounded through the trees and…

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