Leslie Vosshall

Preprints obfuscate facts (1)

How many preprints should be published? If someone posts something crazy like vaccines cause autism, I don’t think respectable news outlets will cover it without first discussing the preprint with experts. The light-activated assembly of the microRNA-RNA-peptide nanocomplex and the cure for all cancer was reported by researchers from Israel and discussion by so-called experts followed: See: A cure for cancer? Israeli scientists say they think they found one 1/28/19 The company is now writing patents on specific peptides, which…

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Creating biophysically constrained viral latency (2)

Creating biophysically constrained viral latency (2) Serious scientists have reached the point where they are finally ready to expose the pseudoscientific nonsense during Evolution – Genetic Novelty/Genomic Variations by RNA Networks and Viruses and also during Schrödinger at 75 – The Future of Biology – September 2018. Until then, pseudoscientists may want to see these examples of accurate information about top-down causation. MicroRNA Processing Gene Methylation and Cancer Risk Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively…

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For God and Country

Kinetically Stable Thermodynamically Activated Cell Metabolism (3)

See: The vibrational theory of olfaction for the win The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria. See also: The Influence of Circadian Timing on Olfactory Sensitivity Reported as: The Circadian Clock in Your Nose “The results make sense — the…

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The next reformation: 500 years too late? (1)

Summary: The next reformation links the creation of the sense of smell to all biodiversity in the context of biophysically constrained viral latency. The vibrational theory of olfaction for the win Although there is nothing comparable to this kind of insight into the molecular world of scent within the shapist mentality, we should probably thank its supporters for making this battle of ideas so epic. There may yet be time for two more big events in the field, one a…

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The next reformation: 500 years too late? (2)

The problem for those who use definitions is that everything known about the links from food energy-dependent changes in electrons to ecosystems must now be ignored. Last week, publications in Nature and in Science linked energy-dependent changes in base editing to RNA editing, which means that all the ignorance of biologically uninformed theorists can be placed into the context of Feynman’s claims about “human idiocy.” See also: RNA editing and alternative splicing: the importance of co-transcriptional coordination Apparently, the theorists…

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Eliminating correlations from evolutionary ecology

De novo creation of olfactory receptor genes clearly links food odors via amino acid substitutions to cell type differentiation in mosquitoes, and in nematodes, flies, honeybees, etc. It would be surprising if cause and effect did not extend to vertebrates from invertebrates. Indeed, Elekonich and Robinson (2000) linked our 1996 model of RNA-mediated cell type differentiation to hormone-organized and hormone-activated behavior in insects more than a decade ago. Since then, Vosshall’s lab has established the role that amino acid substitutions…

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