light-activated carbon fixation

God’s microRNA-mediated Creation of genotypes (5)

September 21, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Energy-dependent changes in single nucleotide polymorphisms (SNPs) in microribonucleic acids (microRNAs/miRNAs) were linked from femotosecond blasts of UV light to DNA repair via an extremely sensitive assay for the label-free optical detection and suppression of interfering effects caused by non-specific binding. Interactions in Augmented and Mixed Reality: An Overview 9/20/21 (This article belongs to the Special Issue Extended Reality: From Theory to Applications) All interactions are energy-dependent and microRNA-mediated. ~250 newly indexed articles attest to that fact, which is…

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God’s microRNA-mediated Creation of genotypes (1)

September 8, 2021
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
One Comment

See first: Natural selection for adaptation (10) DNA Logic Circuits for Multiple Tumor Cells Identification Using Intracellular MicroRNA Molecular Bispecific Recognition  9/5/21 The bispecific intracellular miRNA controllable DNA circuit…easily extends to various cell type discrimination by adjusting the [energy-dependent biophysically constrained Creation of] miRNA species… When Fauci claimed it was molecularly impossible to engineer SARS-CoV-2 in the Wuhan lab, the extent of his lies became clear. The fact that he lied before Congress is now clearer. See: Learning noncoding RNA…

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Natural selection for adaptation (10)

September 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18 Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications…

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MicroRNA-mediated population control (5)

July 30, 2021
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 and Visualization and characterization of RNA–protein interactions in living cells 7/27/21 cannot be linked to stupid theories about the automagical emergence of energy from the cosmic void or theories that link beneficial mutations during the past billions to millions of years to our evolution from pond scum or light-activated carbon fixation in cyanobacteria. For contrast, the visualizations support this claim: “Post-transcriptional modifications, especially phosphorylation play crucial roles in regulation of…

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MicroRNA-mediated population control (1)

July 23, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, What's in the News
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Your expectations and hope alter your chances of recovery. WHO wants you to give up hope and accept synthetic mRNA vaccines to prevent your recovery by causing more virus-driven diseases, which will  not help to end the SARS-CoV-2 pandemic. RNA interference, the 2002 “breakthrough of the year” will end the SARS-CoV-2 pandemic. In 2002, on the heels of the discovery that RNA interference existed in human cells, the usually reserved journal Science proclaimed RNAi the “breakthrough of the year.” Breakthrough…

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microRNA-mediated replication cycles (9)

July 6, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic
One Comment

See first: microRNA-mediated replication cycles (8) Rotavirus research: 2014-2020 7/2/21 A temperature sensitive mutant… in the triplet encoding amino acid 138 of VP1 (L138P)…was separately expressed as a… protein, shown to interact with viroplasm-like particles (VLPs) in uninfected cells and to synthesize RNA in vitro…” My summary: The rotavirus steals the energy required for the ATP-dependent synthesis of RNA, which typically biophysically constrains viral latency across kingdoms. Contextual constraints occur via light-activated carbon fixation, oxidative phosphorylation and RNA interference (RNAi).…

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microRNA-mediated replication timing (1)

June 17, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
2 Comments

The phylogenetic utility and functional constraint of microRNA flanking sequences links the patent for naturally occurring light-activated carbon fixation to viral latency and healthy longevity across kingdoms. The patent: RNA-Guided Human Genome Engineering was linked from functional constraints to gain-of-function research in High-Quality Overlapping Paired-End Reads for the Detection of A-to-I Editing on Small RNA WHO failed to examine the problems associated with gain-of-function research, which researchers now suggest led to the creation of SARs-CoV-2. The creation of SARs-CoV-2 can be…

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Quantum Darwinism (5)

April 15, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic
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See with my added emphasis: Parallel genetics of regulatory sequences using scalable genome editing in vivo 4/13/21 [Energy-dependent biophysically-constrained microRNA-mediated] Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts. Gene-centric theorists are too stupid to start with God’s Creation of energy, which must be linked from regulatory elements to regulation of the genomic environment before the effects of energy can be understood in any context whatsoever. See for context: Energy as information and constrained…

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Quantum Darwinism (4)

April 15, 2021
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference, What's in the News
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How metformin affects various malignancies by means of microRNAs: a brief review 4/13/21 Metformin adjusts cellular energy metabolism through…an important metabolic sensor that is activated under cellular stress conditions and limits energy consumption by affecting ATP production and consumption [1, 2]. The link from naturally occurring light-activated carbon fixation to God’s ATP-dependent Creation of RNA, protonated RNA interference, and biophysically constrained viral latency became clearer in 1964. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism…

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Quantum Darwinism (1)

April 8, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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See first: Pheromones protect us from viruses parts 1-10 For a historical perspective on the development of healthy ecosystems, see: Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) (1994) and From Fertilization to Adult Sexual Behavior (1996) For links from quantum Darwinism to all energy-dependent biophysically constrained biodiversity, see also: Quantum Criticality at the Origin of Life 3/3/15 The number of proteins grows exponentially with the number n of amino acids… Peptide synthesis at the…

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