longevity

Trashing the 2nd Law

December 9, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, What's in the News
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Summary: Autophagy is the antiphage defense strategy. (December 8, 2016) Other definitions no longer apply. See: Experiment shows that arrow of time is a relative concept, not an absolute one Everything that theorists were taught to believe about entropy was probably based on the ridiculous assumption that “…there are no correlations between particles.” Everything known to serious scientists about energy-dependent autophagy shows that the creation of energy must be linked from the biophysically constrained physiology of pheromone-controlled reproduction via feedback…

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Trump’s appeal to common sense (2)

January 20, 2017
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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See: Trump’s appeal to common sense Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation To our knowledge, this is the first study to use a genetic mouse model to simultaneously map Gpr182 localization patterns and elucidate novel physiological functions for the negative regulation of intestinal proliferative capacity, especially during regeneration and adenoma formation. Future studies to identify the ligand for this exciting and physiologically relevant orphan GPCR [G protein-coupled receptor] will shed light on its tractability as…

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Autophagy is the antiphage defense strategy

December 8, 2016
James Kohl
Autophagy, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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The “Antiphage Defense Strategy” in Vibrio anguillarum is called autophagy by many serious scientists. It links nutrient energy-dependent pheromone-controlled quorum sensing to viral latency, healthy longevity, symbiosis, reproduction, and biodiversity from microbial species to humans. For an evolutionary approach to energy-dependent autophagy that fails to address any aspect of how virus-driven energy theft causes all pathology see: (12/7/16) Part I: Living together: The symbiosis of host-microbial interactions (12/7/16) See also: 12/7/16 ….McFall-Ngai tells the story of a symbiosis between the…

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The futility of The Battlefield FB group

December 2, 2016
James Kohl
Adaptations, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Apparently, Paul Hartley blocked me from further discussion of his OP about dinosaurs and gladiators before I could ask if he thought “The Battlefield” is a “false flag” group. Does anyone else think that?   If so, do you think it can survive publication of experimental evidence that links responsive supramolecular systems to stepwise changes in the assembly of metal complexes via induction of a light-driven rotary motor scaffold akin to the bacterial flagellum of P. fluorescens? See: Dynamic control…

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Base pairs, olfaction and RNA thermometers

September 22, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Did “Nature” kill Steve Jobs?

July 16, 2016
James Kohl
Diseases & Disorders, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See also: Energy-dependent RNA methylation (7) How cancer was created by evolution (revisited) Excerpt: Cell division in our bodies is very heavily controlled. For instance, when you were first growing your hands, some cells went through “cell suicide” – a process called apoptosis – to carve out the spaces between your fingers. My comment: Cell division is energy-dependent and the result is controlled by the physiology of reproduction in species from microbes to humans.  Energy-dependent RNA-mediated cell type differentiation must…

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Model vs theory: Progress report!

June 14, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

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Thermotolerance and longevity (2)

June 1, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Thermotolerance and Longevity This article is part of the Research Topic Brain nutrient sensing in the control of energy balance: new insights and perspectives Excerpt: It is well established that nutrients act as signaling molecules in synergy with nervous and hormonal signals to inform the brain about the nutritional status of the body. The integration of these signals within the hypothalamus and other brain regions triggers behavioral and physiological responses through efferent autonomic nerves, hypothalamic-pituitary-Adrenal and thyroid axis…

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Ricki Lewis’ Time Machine

January 22, 2016
James Kohl
Adaptations, biophotonics, Ecology, Human Pheromones, Light Energy, Model Organisms, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Can a Quirky Chromosome Create a Second Human Species? Excerpt 1) The first departure from the common house mouse (Mus musculus) was the “tobacco mouse” (Mus poschiavinus), described in 1869 from specimens trapped in a tobacco factory in Valle di Poschiavo, Switzerland. They had big heads and small, dark bodies. Excerpt 2) I spoke to Bear back in 2004, again for The Scientist (a mechanism for the rapid extinction of a dedicated freelance writer is a change in editor-in-chief). Greg Bear is…

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Cytogenetic approaches link biosystems to ecosystems

January 22, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems (Original Russian Text E.V. Daev, A.V. Dukelskaya, L.V. Barabanova, 2014, published in Ecologicheskaya Genetika, 2014, Vol. 12, No. 2, pp. 3–12.) For comparison see this open access review: Assessing vertebrate biodiversity in a kelp forest ecosystem using environmental DNA The Russian group seemed to me to be ~20 years ahead of the US-based research group. Eugene Daev explained the differences in the approach taken in the two published works.…

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