Luca Turin

MicroRNA-mediated alternative splicing (revisited)

Building one molecule from a reservoir of two atoms reported as: Cold chemistry with two atoms. They linked differences in the energy of photons from two different wavelengths of light, 700 nm and 976 nm, to the creation of the molecule NaCs*. They were able to detect molecule formation in the context of atom loss and NaCs* vibrational levels near the dissociation threshold. Detecting resonances that have not been previously observed appears to be the link from quantum physics to…

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For God and Country

Kinetically Stable Thermodynamically Activated Cell Metabolism (3)

See: The vibrational theory of olfaction for the win The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria. See also: The Influence of Circadian Timing on Olfactory Sensitivity Reported as: The Circadian Clock in Your Nose “The results make sense — the…

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Trashing the 2nd Law

Summary: Autophagy is the antiphage defense strategy. (December 8, 2016) Other definitions no longer apply. See: Experiment shows that arrow of time is a relative concept, not an absolute one Everything that theorists were taught to believe about entropy was probably based on the ridiculous assumption that “…there are no correlations between particles.” Everything known to serious scientists about energy-dependent autophagy shows that the creation of energy must be linked from the biophysically constrained physiology of pheromone-controlled reproduction via feedback…

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The next reformation: 500 years too late? (1)

Summary: The next reformation links the creation of the sense of smell to all biodiversity in the context of biophysically constrained viral latency. The vibrational theory of olfaction for the win Although there is nothing comparable to this kind of insight into the molecular world of scent within the shapist mentality, we should probably thank its supporters for making this battle of ideas so epic. There may yet be time for two more big events in the field, one a…

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The next reformation: 500 years too late? (2)

The problem for those who use definitions is that everything known about the links from food energy-dependent changes in electrons to ecosystems must now be ignored. Last week, publications in Nature and in Science linked energy-dependent changes in base editing to RNA editing, which means that all the ignorance of biologically uninformed theorists can be placed into the context of Feynman’s claims about “human idiocy.” See also: RNA editing and alternative splicing: the importance of co-transcriptional coordination Apparently, the theorists…

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Model vs theory: Progress report!

On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

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The Mind’s Eyes (revisited)

Author’s copy: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences (2007) Abstract: The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self.  Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response.  The organization and activation of this neuroendocrine response modulates the concurrent maturation of the mammalian neuroendocrine system, the reproductive system, and the central nervous system during the development of sexual preferences that…

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The unoffically uninvited

Who’s Invited to the Royal Society Evolution Paradigm Shift Meeting? – The Unofficial List Excerpt: I was informed by the Royal Society science program office that there will be no formal presentations on viruses, per se, which seems peculiar considering viruses are now understood to be the biggest part of the biosphere, and a key reason for paradigm shift. Viruses and microbes — both organisms — were left out of the modern synthesis. Seriously missing then from the proceedings will…

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A million dollar paradox?

Paradox at the heart of mathematics makes physics problem unanswerable Excerpt 1) Cubitt and his collaborators focused on calculating the ‘spectral gap’: the gap between the lowest energy level that electrons can occupy in a material, and the next one up. My comment: I hesitate to suggest that the problem of the spectral [energy] gap must be placed into the context of what is known about the speed of light on contact with water and how the anti-entropic energy of…

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Hydrogen-Atom Transfer in DNA Base Pairs

I requested a reprint of this article from the senior author on 10/29/15 and received it on 12/18/15.  Scientific progress moves fast, and Hydrogen-Atom Transfer in DNA Base Pairs (2) appears before the continuation of this post is linked to Hydrogen-Atom Transfer in DNA Base Pairs (3) and others in this series. Ultraviolet Absorption Induces Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution [subscription required] It was reported as: Researchers observe one of the world’s fastest chemical reactions…

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