MicroRNAs and the Cassandra syndrome (revisited)

Conclusion: Serious scientists can explain every aspect of energy-dependent biophysically constrained viral latency in the context of details about these pathways and everything that links changes from electrons to ecosystems in all living genera. Why are the serious scientists still challenged by “…the tendency of academia to reject any academic-like work from outside academia?” What aspect of the academic contribution that could lead to the cure for all pathology do biologically uninformed academics want to continue to reject and attack?…

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Epigenetic facts vs variable recombination theories

6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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RNA-mediated adult learning, memory, and neurogenesis

Here is a way to assess the power of the media-industrial complex to suppress accurate representations of biophysically constrained biologically-based cause and effect. Wait to see whether this experimental evidence is reported in the science news, or how it is reported. Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa The experimental data obtained by immunohistochemistry and western blot assay using proliferating cell nuclear antigen and poli (ADP-ribose) polymerase…

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Energy-dependent chirality (2)

See Energy-dependent chirality 2013 MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination See also E. Ben-Jacob Ben-Jacob et al., have linked everything currently known about natural information processing from natural selection for energy-dependent codon optimality to healthy longevity and from virus-driven energy theft to mutations that cause cancer. See for comparison: LH Tsai Tsai laboratory Our primary goal is to elucidate the mechanisms underlying neurological disorders affecting learning & memory. The major research areas include age disorders, autism, and Alzheimer’s disease. 2012…

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Chromatin: The structure of DNA (2)

A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation Excerpt (with my emphasis): Highlights •    A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed. •    Dynamics and replication timing of Xi were visualized. •    Critical amino acids for the stability and/or folding of the mintbody were revealed. Reported as: Catching histones by the tail: A new probe to track histone modifications in living cells Excerpt: H4K20me1 is most likely associated with the tight packing of a redundant (inactivated) female X…

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Did “Nature” kill Steve Jobs? (2)

See also: Did “Nature” kill Steve Jobs? In my model of biophysically constrained energy-dependent protein folding chemistry and RNA-mediated cell type differentiation, the nutrient-dependent pheromone-controlled physiology of reproduction links the innate immune system to supercoiled DNA, which protects all organized genomes from virus-driven entropy. For comparison to my model, see: Evolution 2016 Videos (Indexed) Youtube videos Posters See also for comparison: Viruses Have Guided the Path of Human Evolution Excerpt: Whenever a viral epidemic tears through a community, there are…

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RNA methylation

This is a brief history of events that led me to found the domain with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the gene expression programs that drive experience-dependent plasticity of neural circuits. Recent studies have not only vastly expanded our understanding of the mechanisms that mediate activity-regulated…

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Cytogenetic approaches link biosystems to ecosystems

Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems (Original Russian Text E.V. Daev, A.V. Dukelskaya, L.V. Barabanova, 2014, published in Ecologicheskaya Genetika, 2014, Vol. 12, No. 2, pp. 3–12.) For comparison see this open access review: Assessing vertebrate biodiversity in a kelp forest ecosystem using environmental DNA The Russian group seemed to me to be ~20 years ahead of the US-based research group. Eugene Daev explained the differences in the approach taken in the two published works.…

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RNA methylation, RNA-directed DNA methylation, learning and memory

sink testing Lab medicine The illegal practice of providing false test results on clinical specimens–eg, vials of blood, urine specimens, that were deliberately discarded–ie, down the sink, without actually testing them Pylori Story #1: Acid Attack Pylori Story #2: Journey to the Center of the Stomach The “Modern Synthesis” is analogous to sink testing in the medical laboratory. See for example: Replace the Modern Synthesis (Neo-Darwinism): An Interview With Denis Noble Excerpt: [W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et…

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I forgot. How do mutations cause evolution?

Memories influence choice of food Excerpt: “Our study builds a bridge between two central research fields of psychology, that is, memory and decision-making research,” says Dr. Sebastian Gluth, lead author of the study. The combination of mathematical modeling and brain scans also provides an accurate understanding of how the areas of the brain are linked to the psychological sub-processes and how these areas interact with one another. My comment: An accurate representation of interactions in the brain and psychological sub-processes…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]