metabolism

Color vision refutes the evolutionary dogma of gene duplication

The Rainbow Connection Color vision as we know it resulted from one fortuitous genetic event after another. By Kerry Grens | October 1, 2014 Excerpt 1: “The fact that we have the same few amino-acid substitutions as New World monkeys argues there was a single ancestral variation that gave rise to [the cone opsins of] both Old and New World primates,” Nathans says. “It leads to an interesting twist on the evolutionary dogma of gene duplication.” My comment: The fact…

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Forces of "Nature" limit dissemination of information

Force of nature gave life its asymmetry Excerpt: “In 2011, Meierhenrich and colleages showed4 that such light could transfer its handedness to amino acids. But even demonstrating how a common physical phenomenon would have favoured left-handed amino acids over right-handed ones would not tell us that this was how life evolved, adds Laurence Barron, a chemist at the University of Glasgow, UK. “There are no clinchers. We may never know.” My comment:I think the clincher is the creation of the…

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Different physical locations and different molecular mechanisms of health and disease

Reappraisal of known malaria resistance loci in a large multicenter study Abstract excerpt: “The finding that G6PD deficiency has opposing effects on different fatal complications of P. falciparum infection indicates that the evolutionary origins of this common human genetic disorder are more complex than previously supposed.” Reported as: Long term genetic study finds geographical differences in human immune response to malaria Excerpt: “…humans living in different physical locations have evolved different mechanisms for staving off the dreaded disease malaria.” My…

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Metabolism, fixation, health or neurodegerative disorder

“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.” Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism My comment: The article links a nutrient-dependent amino acid substitution via changes in metabolism to cell type differentiation, multicellularity, and brain development in Drosophila. It suggests the substitution is fixed by the model organism’s pheromone-controlled…

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Epigenetically-effected metabolic shifts and ecological adaptations

Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, monomethylation of histone H3 at lysine 4, and acetylation of histone H3 at lysine 27. They also analyzed genome-wide transcription and transcription factor binding. Together…

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Stop evolutionary theorists. Kill cancers

Bacterial ‘communication system’ could be used to stop, kill cancer cells, study finds Excerpt: “During an infection, bacteria release molecules which allow them to ‘talk’ to each other,” said the lead author of the study. “Depending on the type of molecule released, the signal will tell other bacteria to multiply, escape the immune system or even stop spreading.” My comment: Nutrient-dependent cell type proliferation is pheromone-controlled during health and infections — and in other diseases and disorders. The conserved molecular…

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De novo gene Creation sans evolution of genes via mutations

Where do genes come from? – Carl Zimmer The pseudoscientific nonsense touted in this video has been refuted by decades of experimental evidence. The experimental evidence links RNA-directed DNA methylation from nutrient-dependent amino acid substitutions to the de novo Creation of olfactory receptor genes and fixation of amino acid substitutions in the DNA of organized genomes. Fixation occurs via the nutrient-dependent pheromone-controlled physiology of reproduction in species from microbes to man. Evolution: Dynamics of De Novo Gene Emergence “…it was…

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RNA-directed DNA methylation and RNA-mediated events

Many colleagues and most of my antagonists seem to be unwilling to accept the fact that RNA-directed DNA methylation links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. Lack of acceptance appears to be due to the fact that they think mutations and natural selection link evolutionary events to biodiversity. There is no model for that, but they refuse to accept the fact that RNA-mediated events link ecological variation…

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Miracles are not miracles to evolutionary theorists

Science 19 September 2014: Vol. 345 no. 6203 pp. 1443-1445 DOI: 10.1126/science.345.6203.1443 No miracles Excerpt: “There’s a reason these crows make tools and other birds don’t,” he says. “It’s not a miracle.” THAT SENTENCE, along with the even shorter phrase “no miracles,” is a favorite of Gray’s. The power of evolution “to explain many things,” as he puts it, struck him when he was still in high school in Tauranga, south of Auckland, after reading Richard Dawkins’s The Selfish Gene.”…

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Watching and waiting for more retractions

Brain Genetics Paper Retracted A study that identified genes linked to communication between different areas of the brain has been retracted by its authors because of statistical flaws. By Anna Azvolinsky | September 4, 2014 Excerpt: “This retraction raises the issue of how many papers may have falsely reported gene associations because of the constantly evolving changes in gene assemblies and boundaries. That’s really alarming to me.” My comment: I am alarmed by those who report anything in terms of…

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