Methylation

Wars caused by metaphors: 1964

Theorists tend to use metaphors to support their stupid theories. Intelligent serious scientists consistently use facts. For example, researchers from Japan and the USA attacked the Chinese Communist Party’s representations of naturally evolved virus-driven pathology with claims in Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197 6/11/21 …the first example of modulation of activity of endogenous noncoding RNA using M-modified triplex-forming PNA. It is clear that peptide synthesis at the origin of life is linked from biophysically…

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Methylation and the Innate Immune System

Free Webinar Training: Methylation and the Innate Immune System Free Training: Methylation and the Innate Immune System Please send your questions, comments and feedback to: support@qahomestudy.com I sent these two questions in advance: 1) Does what organisms eat link food energy to RNA-directed DNA methylation and all healthy longevity via fixation of amino acid substitutions and transgenerational epigenetic inheritance in the context of the physiology of pheromone-controlled reproduction in species from microbes to humans? 2) Does the virus-driven theft of…

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Energy-dependent physical and biophysical constraints (10)

Summary: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis…— Eugene Koonin My comment: Viruses are not life forms. They steal the quantized energy that links sunlight to viral latency in the context of everything known to all serious scientists about the fact that Feedback loops link odor and pheromone signaling with reproduction See for comparison: Olfaction Warps Visual…

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Dispensing with all pseudoscientific nonsense about evolution (2)

Dispensing with all pseudoscientific nonsense about evolution (1) See also: Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk Reported as: Hundreds of Genomic Regions Linked to Age at Menarche Age at onset of puberty is affected by a combination of genetic, nutritional, and other environmental factors and that timing, in turn, is associated with risk of cancer later in life. Who will be next to link energy-dependent…

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Functionally interdependent editing and methylation

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C is deaminated to 3-methyluridine (m3U) by the same set of enzymes. ADAT2/3 is a highly mutagenic enzyme4, but we also show that when co-expressed with…

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Energy-dependent pheromone-controlled entropy (2)

See also: Energy-dependent pheromone-controlled entropy (1) Let’s make peer review scientific …peer review is often biased and inefficient. It is occasionally corrupt, sometimes a charade, an open temptation to plagiarists. Even with the best of intentions, how and whether peer review identifies high-quality science is unknown. It is, in short, unscientific. The androgynous baby-faced boy or girl pictured among those wearing pink “crotch” hats appears to representing others at the March for Women. The sign may also be representing the…

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The essence of precision medicine: drug targets or healthy longevity?

The molecular epigenetics of healthy longevity Trichome, a Functional Diversity Phenotype in Plant Abstract: Trichomes play a very important role in the process of evolution for plant which are epidermal appendages covering the surface of plants. In this paper, some progress concerning the genes responsible for trichome formation is presented for monocots and dicotyledons plants. Meanwhile, the special structures and physiological functions of trichome are briefly introduced, such as reflectance, energy balance, ultraviolet protection, drought resistance, gas exchange, insect resistance…

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Energy-dependent de novo creation and neurogenesis

See also: Tasting light links energy from creation to adaptation Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning reported as: When neurons are ‘born’ impacts olfactory behavior in mice My summary: The de novo creation of different cell types is placed into the context of their energy-dependent birth and the transgenerational epigenetic inheritance of molecular mechanisms that link virus-driven energy theft to all pathology via olfaction, food odors, and human pheromones. See for comparison: Metabolism and neurogenesis …it…

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Theories vs facts about polycombic adaptation

See: Demoncrats fight polycombic ecological adaptation Exosomes as miRNA Carriers: Formation–Function–Future Important aspects will be highlighted as a take-home message (THM) at the end of each paragraph. THM: Extracellular vesicles transport miRNA in a paracrine and endocrine manner. Questions regarding the cellular options of producing either microvesicles or exosomes and their difference in miRNA composition and number are still unknown. In my 2014 invited review, the four F’s, Formation–Function–Future and Copulation were included in details about how the nutrient energy-dependent…

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Survivors of RNA-mediated terrorism

In Darwin’s Radio and Darwin’s Children, Greg Bear predicted there would be ecologically adapted survivors of the forthcoming viral apocalypse.  Could his “raw insight” help to save you, or help to save any of your loved ones who are not already dead? Or, is it too late for us all? See: “The Darwin Code: Intelligent Design without God” Excerpt:  Once again, evolution is a fresh territory, much larger than anyone thought. The Darwin code–the key to all of our new…

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