A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation Excerpt (with my emphasis): Highlights • A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed. • Dynamics and replication timing of Xi were visualized. • Critical amino acids for the stability and/or folding of the mintbody were revealed. Reported as: Catching histones by the tail: A … Chromatin: The structure of DNA (2)
See also: Energy-dependent RNA methylation (7) How cancer was created by evolution (revisited) Excerpt: Cell division in our bodies is very heavily controlled. For instance, when you were first growing your hands, some cells went through “cell suicide” – a process called apoptosis – to carve out the spaces between your fingers. My comment: Cell … Did “Nature” kill Steve Jobs?
This is a brief history of events that led me to found the domain RNA-mediated.com with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the … RNA methylation
Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein 5/6/16 Summary excerpt: Visualizing a response to light Many biological processes depend on detecting and responding to light. The response is often mediated by a structural change in a protein that begins when absorption of a photon causes isomerization of a chromophore bound to … RNA-mediated physics, chemistry, and molecular epigenetics (4)
The light of evolution in the oft-cited work by Dobzhansky (1973) is the energy from sunlight. The sun’s biological energy links its anti-entropic virucidal epigenetic effects to RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera. Excerpt from Dobzhansky (1973) …the so-called alpha chains of hemoglobin have identical … The Light and Darkness of “Evolution 2.0”
See also: Hydrogen-atom transfer in DNA base pairs (5) Hydrogen-atom transfer in DNA base pairs (5) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Excerpt: …methylation of the carbon-5 position of cytosine, which results in differences in 5hmCs, may be the most commonly studied type of nutrient-dependent pheromone-controlled structural and functional eukaryotic modification that results … Cancer: Evolution 2.0’s Blind Spot
Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress Excerpt: To visualize the stress-reactive profiles across genotypes, a heat map with hierarchical clustering of the mean relative difference “stress–resting” was generated, demonstrating that each mitochondrial defect induced a different amino acid response signature (Fig. 4F). In particular, the stress-reactive amino acid … Stress-perturbed mitochondrial dysfunction
See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this: Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much … Theorists can’t understand biology
First Complete Pictures of Cells’ DNA-Copying Machinery Excerpt: This architecture could also potentially play an important role in developmental biology by providing a pathway for treating the two daughter strands differently. Many modifications to DNA, including how it is packaged with other proteins, control which of the many genes in the sequence are eventually expressed … The virome, microbiome, replisome and supercoiled DNA
There are foundations of epigenetics and fundamentals of molecular mechanisms. They have been detailed in this atoms to ecosystems model of RNA-mediated cell type differentiation. Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems. I have never seen anyone mention the “foundamentals” of epigenetics. It appears the word has been invented. Similarly, the word “mutation” was … Foundamentals of theory
