Michael Guttman

RNA-mediated silencing of a chromosome

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3was reported as: How an RNA gene silences a whole chromosome Summary: “Researchers have discovered how an abundant class of RNA genes, called lncRNAs can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group RNA-mediated silencing of a chromosome