microbiology

Part 2: Light-controlled cell biology (revisited)

Greg Bear took the lead with this approach in his novel Quantico (2006). A genetically engineered virus was used to erase the memory of a specifically targeted human population to reduce inter-ethnic conflict. [Greg Bear] …served as a consultant for NASA, the U.S. Army, the State Department, the International Food Protection Association, and Homeland Security on matters ranging from privatizing space to food safety, the frontiers of microbiology and genetics, and biological security. Greg Bear is a likely candidate for…

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Evolutionary theories of epigenetic drift (3)

Researchers unite in quest for ‘standard model’ of the brain Modelled on big physics projects, the International Brain Lab will bring together some of the world’s pre-eminent neuroscientists to probe a single behaviour. Foraging The IBL will aim to generate and test unifying theories about how the brain encodes and computes information – seeking to come up with the equivalent of physicists’ standard model. See also: microRNA foraging See for example: The Drosophila foraging gene human orthologue PRKG1 predicts individual…

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Host-derived creation of all pathology (2 of 2)

Summary: All serious scientists know that all epigenetic diversity is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. See for comparison: Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.” A Bacterial Messenger Molecule Extends Healthspan …indole,…

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Energy-dependent physical and biophysical constraints (3)

See first: Energy-dependent physical and biophysical constraints (2) Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction. See: Feedback loops link odor and pheromone signaling with reproduction My comment to The Scientist: …trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an…

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Creating genes and species

The Octopus Genome: Not “Alien” but Still a Big Problem for Darwinism by Casey Luskin, August 24, 2015 Excerpt: Whenever you see “de novo” origin of a gene invoked, you know that evolutionary biologists lack any explanation for how that gene arose. My comment: I tend to use the experience-dependent “de novo” creation of olfactory receptor genes as an example of how RNA-mediated events link physics, chemistry, and biology from atoms to ecosystems via the conserved molecular mechanisms of biophysically…

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Beneficial microbes kill beneficial mutations

Microbiology: Here’s looking at you, squid Margaret McFall-Ngai has dissected the relationship between a beautiful squid and its live-in bacteria — and found lessons for microbiome research on the way. Ed Yong 14 January 2015 Excerpt: “We now know that microbes make up the vast diversity of the biosphere, and that animal biology was shaped by interacting with microbes,” she says. “In my mind, this is the most significant revolution in biology since Darwin.” My comment: I agree. Darwin’s works…

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Stop evolutionary theorists. Kill cancers

Bacterial ‘communication system’ could be used to stop, kill cancer cells, study finds Excerpt: “During an infection, bacteria release molecules which allow them to ‘talk’ to each other,” said the lead author of the study. “Depending on the type of molecule released, the signal will tell other bacteria to multiply, escape the immune system or even stop spreading.” My comment: Nutrient-dependent cell type proliferation is pheromone-controlled during health and infections — and in other diseases and disorders. The conserved molecular…

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RNA-mediated species diversification from microbes to primates

Mycobacteriophage-drived diversification of Mycobacterium abscessus Biology Direct (15 September 2014) OPEN ACCESS Excerpt (with my emphasis): “Widespread occurrence of phage sequences in almost all studied M. abscessus complex isolates suggests that the rate of prophage invasion is faster than the rate of mutation, implying rapid evolution of M. abscessus.” My comment: The faster rate of prophase invasion suggests ecological adaptations occur more rapidly than evolution. That may be why no experimental evidence of biologically-based cause and effect suggests that evolution…

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Nutrient-dependent erythropoiesis and anemia

A critical role for mTORC1 in erythropoiesis and anemia Excerpt 1): “Cells must coordinate their rate of growth and proliferation with the availability of nutrients. mTOR , a serine-threonine kinase, is one the key proteins responsible for nutrient signaling in eukaryotic cells. mTOR is activated by conditions that signal energy abundance, such as the availability of amino acids, growth factors, and intracellular ATP. Activated mTOR then phosphorylates a set of downstream targets that promote anabolic processes, such as protein translation…

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