microRNA biogenesis

Pheromones protect us from viruses (9)

It may be a form of insanity that prevents theorists, atheists, and Communists from addressing the facts that have been detailed in the context of: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 …a class of agents called covalent peptidomimetic inhibitors that work by using strings of unnatural amino acids to bind to specific target proteins. See for instance:  A two-amino acid change in the hemagglutinin of the 1918 influenza virus…

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Impeaching the God of Abraham (2)

Origins of modern human ancestry 2/10/21 …no specific point in time can currently be identified at which modern human ancestry was confined to a limited birthplace… This was reported as: On the origin of our species “…neither the genetic or fossil record have so far revealed a defined time and place for the origin of our species.” See for comparison: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk…

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Heliotropic Helioribogenetic Creation of Heliorhodopsin (1)

See: Crystal structure of heliorhodopsin 9/25/19 for the link from God’s heliotropic hydrogen-dependent helioribogenetic Creation of heliorhodopsin to our visual perception of energy and mass across the time-space continuum. Hydrophobic residues fill the space in the extracellular half of HeR, preventing the permeation of protons and ions. God’s Creation of hydrogen is the link to the creation of of protons to pH-dependent hydrophobic residues. See: Human Vision Can Sense a Single Photon 8/8/16 To our knowledge, these experiments provide the…

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Coherently organized healthy longevity (2)

RNA-mediated.com Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift. Within 8 hours from the time I posted Coherently organized healthy longevity (1) to my blog site at RNA-mediated.com, Quanta Magazine regurgitated this claim from 1/3/19 Quantum error-correcting codes are essential for protecting information in quantum computers. They may also be responsible for…

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Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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pH-dependent viral latency (7)

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots  6/12/20 …we demonstrate that the RNA mutation-based APOBEC3A assay is applicable to clinical samples from cancer patients. Our study presents a strategy to follow the dysregulation of APOBEC3A in tumors, providing opportunities to investigate the role of APOBEC3A in tumor evolution… Reported as: Monitoring RNA hotspots reveals target in cancer tumor cells by University of California, Irvine The targeting is microRNA-mediated. Proteins do not create themselves…

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The microRNA-mediated future of humanity (3)

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper Patient-derived mutations impact pathogenicity of SARS-CoV-2 We observed intrapersonal variation and 6 different mutations in the spike glycoprotein (S protein), including 2 different SNVs that…

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Natural models inspire future therapeutics

Natural models inspire future therapeutics See: Screaming viruses and Alzheimer’s (1) Screaming viruses and Cancer Screaming Viruses and Alzheimer’s (2) MicroRNA biogenesis, the microRNAome, and your brainome and Reciprocal Interactions Between Gut Microbiota and Host Social Behavior We suggest that investigating these reciprocal interactions can advance our understanding of sociality, from healthy and impaired social cognition to the evolution of specific social behaviours and societal structure. There is no natural model of evolved social behavior. I suggest that all theorists…

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An evolutionary theory killer

The concept of a species (3)

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

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The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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