microRNA biogenesis

Epistemic corruption (10)

Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly 5/26/22 Full functional evaluation of the recombinant key enzymes in vivo and in vitro, individually and in concert, provided in-depth mechanistic insights into a streamlined C–C bond-forming cascade that involves installation of compatible reactivity at seemingly unreactive Cα positions of amino acid precursors. Our work extends the biosynthetic and biocatalytic toolbox for γ-butyrolactone formation, provides a general paradigm for furanolide biosynthesis and sets the stage for their targeted discovery, biosynthetic…

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RNA-mediated silencing (7)

On 3/24/22 Reversing the miRNA -5p/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs linked quantum coherence to coherently organized biology and quantum souls via a change in the first nucleotide in miR-140. The energy-dependent change in the first nucleotide linked Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life (4/25/20) to Functions and underlying mechanisms of miR-650 in human cancers and Identifying the oncogenic potential of gene fusions exploiting miRNAs 3/24/22 Three of the 4…

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RNA-mediated silencing (2)

Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators? 3/12/22 God’s Creation of sunlight and humidity at the origin of life ~6000 years ago links light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and healthy longevity across kingdoms via the number of regulators. Fixation of amino acid substitutions is the link to viral endemicity. The facts are clear in: Cellulose: A Plant Cell Biology Game , a STEM toy for ages 14+, which links God’s Creation…

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RNAi 2002 to AI 2021 (8)

Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes 8/12/19 To test whether the inclusion of amino acids addresses this problem, we coupled direct techniques of cryoelectron microscopy and fluorescence microscopy Reported as:  First cells may have emerged because building blocks of proteins stabilized membranes 8/12/19 The stability of membranes is hydrogen-bond (pH) dependent. Nothing known to intelligent serious scientists about top-down causation suggests that stability of cell membranes automagically emerged. See for comparison:  microRNA More than 133,000…

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RNAi 2002 to AI 2021 (7)

I found this claim in an unpublished blog post from 4/14/15 while attempting to update other posts. Most of more than 1600 are missing the focus keyphrase “microRNA” …the control of cellular and organism-wide homeostasis by the epigenetic effects that inhibit viral replication (e.g., proper nutrition and social stress inhibition), might be the best approach to prevent our evolution to another species, or our diet-driven and social stress-driven extinction. See: Epigenetic effects of viruses on cellular homeostasis 10/29/12 Historical perspective:…

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Orchestrated death of Jews et al., by Egyptians (1)

See first: Orchestrated death: Francis S. Collins (2) Exogenous miRNAs induce post-transcriptional gene silencing in plants 10/14/21 was reported on 10/21/21 as Plants Use RNA to Talk to Neighbors A study finds that plants sharing the same growth medium can exchange microRNAs that silence genes in the recipient, suggesting the nucleic acids may act as signaling molecules. Light-activated microRNA biogenesis in plants has been linked from food energy-dependent pheromone-regulated genetic processes of reproduction across kingdoms via the role of nucleic…

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Orchestrated death: Francis S. Collins (2)

See first: Orchestrated death: Francis S. Collins Conclusion: He had the responsibility to not fund the gain-of-function research that led to the loss of our freedoms in the USA. Instead, he failed to mention anything about microRNAs and the fact that miR-155 regulates both adaptive and innate immune responses. Moving forward: Exogenous miRNAs induce post-transcriptional gene silencing in plants 10/14/21 was reported on 10/21/21 as Plants Use RNA to Talk to Neighbors A study finds that plants sharing the same…

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Orchestrated death: Francis S. Collins

MicroRNA-155 and antiviral immune responses 10/8/21 The microRNA, miR-155 regulates both adaptive and innate immune responses. …dysregulated expression of miR-155 can result in virus persistence and disruption of the normal response to viral infections. This collaboration among researchers from Iran, UCLA, and South Africa attests to facts that led Francis S. Collins to resign as NIH director. See first: Collins was the first to plan his escape from prosecution. Watch this blog site as others get thrown under the bus…

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God’s microRNA-mediated Creation of genotypes (9)

Watch for the 2021 Nobel Prize in Chemistry (10/6/21) to be linked from claims about the diet of moths and their physiology of reproduction to today’s resignation of NIH Director, Francis S. Collins, or to corruption among members of the Nobel Prize Committee. With few exceptions, awards in the “hard sciences” (Physics, Chemistry, Physiology and Medicine) link the light-activated proton motive force from the ATP-dependent Creation of microRNAs, RNA, and RNA interference to the pH-dependent physiology of reproduction across kingdoms…

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MicroRNA-mediated population control (9)

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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