microRNA biogenesis

Coherently organized healthy longevity (1)

A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

Read More

pH-dependent viral latency (7)

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots  6/12/20 …we demonstrate that the RNA mutation-based APOBEC3A assay is applicable to clinical samples from cancer patients. Our study presents a strategy to follow the dysregulation of APOBEC3A in tumors, providing opportunities to investigate the role of APOBEC3A in tumor evolution… Reported as: Monitoring RNA hotspots reveals target in cancer tumor cells by University of California, Irvine The targeting is microRNA-mediated. Proteins do not create themselves…

Read More

The microRNA-mediated future of humanity (3)

Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper Patient-derived mutations impact pathogenicity of SARS-CoV-2 We observed intrapersonal variation and 6 different mutations in the spike glycoprotein (S protein), including 2 different SNVs that…

Read More

Natural models inspire future therapeutics

Natural models inspire future therapeutics See: Screaming viruses and Alzheimer’s (1) Screaming viruses and Cancer Screaming Viruses and Alzheimer’s (2) MicroRNA biogenesis, the microRNAome, and your brainome and Reciprocal Interactions Between Gut Microbiota and Host Social Behavior We suggest that investigating these reciprocal interactions can advance our understanding of sociality, from healthy and impaired social cognition to the evolution of specific social behaviours and societal structure. There is no natural model of evolved social behavior. I suggest that all theorists…

Read More
An evolutionary theory killer

The concept of a species (3)

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction (2005) This remodeling of LH circuitry could contribute to the chronic deficit in reward function that has been hypothesized to drive the transition to drug addiction. Lena D. van der Stap discussed her role in the publication of this article, which failed to make any assumptions about mutations and/or evolution. James Kohl Did you co-author Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction McEwen told…

Read More

The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

Read More
An evolutionary theory killer

ATP and RNA-mediated chromosomal stability

Cytosis, a cell biology game for ages 10+ links ATP to viral latency and the protection of all organized genomes from the virus-driven degradation of messenger RNA that serious scientists have linked to all pathology. It is time for a new measure of cell function: Quantifying Cellular ATP Production Rate…(2018) Adenosine triphosphate (ATP) is the most common high energy intermediate of living organisms. Cells utilize the energy derived from the breakdown of cellular fuels to synthesize ATP from ADP and…

Read More

Environmental selection is natural selection (3)

From algae blooms to cancer or prevention Pristine Blue Waters of Boracay Turn Green Ahead of Closure This happens when people ignore facts about how the creation of light and the naturally occurring fixation of light is linked to all biodiversity on Earth via the physiology of reproduction.   MicroRNA-mediated changes in the fixation of RNA-mediated amino acid substitutions favor replication of viruses in the algae. Changes in the microRNA/messenger RNA balance cause the proliferation of the algae that closed…

Read More
For God and Country

Abiogenesis vs microRNA biogenesis (2)

All serious scientists learned about Schrödinger’s claims in “What is Life?” (1944).  All serious scientists have since linked the creation of the sun’s anti-entropic virucidal energy to “negentropy” and healthy longevity. See also: Reappraising the human mitochondrial DNA recombination dogma …paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.   Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction. See the works of those who are scheduled to present during Schrödinger at…

Read More

Abiogenesis vs microRNA biogenesis

Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories. See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group: ——————————- Abiogenesis (2017) Microscopic dissipative structuring and proliferation at the origin of life (Oct 13, 2017) Some fundamental molecules…

Read More