microRNA flanking sequence

Ecological adaptation: A new definition of heredity (3)

Excerpt: Moving forward: Novel and Haplotype Specific MicroRNAs Encoded by the Major Histocompatibility Complex …these data suggest that a subset of the identified novel miRNAs may contribute to the pathophysiology of numerous diseases, laying the groundwork for future studies to elucidate the functional connections of miRNAs to the numerous diseases associated with sequence variants within non-coding regions of the MHC. OMCD: OncoMir Cancer Database Dysregulation of miRNAs is commonly observed in cancers and it largely cancer dependent. The virus-driven theft…

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Trump’s appeal to common sense (2)

See: Trump’s appeal to common sense Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation To our knowledge, this is the first study to use a genetic mouse model to simultaneously map Gpr182 localization patterns and elucidate novel physiological functions for the negative regulation of intestinal proliferative capacity, especially during regeneration and adenoma formation. Future studies to identify the ligand for this exciting and physiologically relevant orphan GPCR [G protein-coupled receptor] will shed light on its tractability as…

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The tipping point? 50,000 publications (4)

The National Microbiome Event has now been placed into the context of the Precision Medicine Initiative. Taken together, metabolic networks are linked to genetic networks via energy-dependent RNA-mediated protein folding chemistry in the context of changes in microRNA flanking sequences that link hydrogen-atom transfer in DNA base pairs in solution from energy-dependent changes in base pairs to the physiology of reproduction and cell type differentiation in all living genera. But see: A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1…

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Countdown to Genetics and Genomics

RNA-mediated physics, chemistry, and molecular epigenetics (5) 5/10/16 Focus: Functional Implications of Human-Specific Changes in Great Ape microRNAs RNA-mediated physics, chemistry, and molecular epigenetics (4) 5/9/16 Focus: Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein RNA-mediated physics, chemistry, and molecular epigenetics (3) 5/9/16 Focus: Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism RNA-mediated physics, chemistry, and molecular epigenetics (2) 5/6/16 Focus: Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton RNA-mediated physics, chemistry,…

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