microRNAs

Natural selection for adaptation (10)

September 7, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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See: Ignoring light-activated microRNA biogenesis 10/16/18, and compare our section on pre-mRNAs and molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996) to MicroRNAs buffer genetic variation at specific temperatures during embryonic development 10/16/18, which was previously published sans mention of microRNAs as Temporal development of Drosophila embryos is highly robust across a wide temperature range 7/11/18 Changing the term from pre-mRNAs to microRNAs obfuscated food energy-dependent pheromone-regulated genetic processes of cause and effect, but see ~127,000 indexed publications…

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Quantum Darwinism (4)

April 15, 2021
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference, What's in the News
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How metformin affects various malignancies by means of microRNAs: a brief review 4/13/21 Metformin adjusts cellular energy metabolism through…an important metabolic sensor that is activated under cellular stress conditions and limits energy consumption by affecting ATP production and consumption [1, 2]. The link from naturally occurring light-activated carbon fixation to God’s ATP-dependent Creation of RNA, protonated RNA interference, and biophysically constrained viral latency became clearer in 1964. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism…

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Impeaching the God of Abraham (1)

February 11, 2021
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA interference, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, What's in the News
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2/10/21 Researchers who share the Abrahamic faiths have refuted the pseudoscientific nonsense touted by all atheists. See: microRNA 115, 376 results There are currently 1052 results for microRNA and Israel 2,063 results for microRNA and Iran 2414 results for microRNA and Korea For a historical perspective on what is known to all intelligent serious scientists about biophysically constrained viral latency across kingdoms see the references from: Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1…

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Coherently organized healthy longevity (4)

September 25, 2020
James Kohl
Alternative Splicings, Autophagy, base editing, RNA Directed
One Comment

See first: Coherently organized healthy longevity (3) “Perfect Pairing” prevents cancer and all other forms of virus-driven pathology. Biologically uninformed science idiots have placed everything known to serious scientists about biophysically constrained “perfect pairing,”microRNA-mediated viral latency, and healthy longevity into the context of computational biology and chemistry via theoretical pairing. See their ridiculous claim in Computational prediction of miRNA/mRNA duplexomes at the whole human genome scale reveals functional subnetworks of interacting genes with embedded miRNA annealing motifs …a very large…

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An evolutionary theory killer

Cardiac energy metabolism requires units of energy

June 14, 2018
James Kohl
Adaptations, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism (First published May 17, 2018 ) Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and βHAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation. The virus-driven theft of quantized energy causes the silencing of mRNA, which generally controls amino…

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MicroRNA-mediated alternative splicing (revisited)

June 7, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Subatomic
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Building one molecule from a reservoir of two atoms reported as: Cold chemistry with two atoms. They linked differences in the energy of photons from two different wavelengths of light, 700 nm and 976 nm, to the creation of the molecule NaCs*. They were able to detect molecule formation in the context of atom loss and NaCs* vibrational levels near the dissociation threshold. Detecting resonances that have not been previously observed appears to be the link from quantum physics to…

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The eternal significance of microRNAs and the Vietnam Memorial (1)

May 31, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA–Mediated Epigenetic Heredity
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Researchers who believe in the mutation-driven evolution of species and mutation-driven differences in human populations have invented another ridiculous hypothesis. Now, they believe in mathematical models that infer: Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck In human populations, changes in genetic variation are driven not only by genetic processes, but can also arise from cultural or social changes. An abrupt population bottleneck specific to human males has been inferred across several Old World (Africa,…

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Cracks in The Granite Wall (1)

May 17, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Researchers in Thailand linked US military service in Thailand during the time of the war in Vietnam from the time of the Korean War to denuclearization of North Korea via energy-dependent changes in the influenza B virus.   From scientific creationists in South Korea: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses   They obviously know how to create a virus that would decimate human populations in North Korea and in other…

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The eternal significance of microRNAs (8)

May 15, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
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Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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MicroRNA-mediated autophagy, denuclearization and eusociality

May 1, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, microRNA editing, RNA Directed
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Altruism in a volatile world reported as: The Elusive Calculus of Insects’ Altruism and Kin Selection In 1964, the evolutionary biologist William D. Hamilton seemingly explained one of the greatest paradoxes in biology with a simple mathematical equation. He will be remembered by all serious scientists for his ignorance of top-down energy-dependent causation. For comparison, McEwen et al. (1964), explained energy-dependent ecological adaptation and sympatric speciation by starting with the energy-dependent creation of RNA. See: Dependence of RNA synthesis in…

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