microRNAs

The eternal significance of microRNAs (2)

April 12, 2018
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril. The Immune Landscape of Cancer (2018) Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune…

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The eternal significance of microRNAs (1)

April 10, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Common Allele Linked to Sugar Consumption Leads to Lower Body Fat, Higher Blood Pressure One energy-dependent change in a base pair is linked from the FGF21 rs838133 variant to microRNA-mediated changes in morphology and behavior. The quantized energy as information link from microRNAs to morphology and behavior is common to my mouse-to-human model of sympatric speciation. By linking the common allele to sugar consumption, the authors attest to the fact that sympatric speciation is quantized energy-dependent. Energy as information biophysically constrains…

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Part 2: Light-controlled cell biology (revisited)

March 23, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, RNA Directed
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Greg Bear took the lead with this approach in his novel Quantico (2006). A genetically engineered virus was used to erase the memory of a specifically targeted human population to reduce inter-ethnic conflict. [Greg Bear] …served as a consultant for NASA, the U.S. Army, the State Department, the International Food Protection Association, and Homeland Security on matters ranging from privatizing space to food safety, the frontiers of microbiology and genetics, and biological security. Greg Bear is a likely candidate for…

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Polymaths and paradigm shifts: from Asimov to Bear (2)

March 14, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Polymaths and paradigm shifts: from Asimov to Bear (1) See also: Search results for virus-driven energy theft Summary: The creation of enzymes, such as ATP synthase is energy-dependent. The energy biophysically constrains viral latency via the creation of microRNAs and RNA-mediated amino acid substitutions that differentiate the cell types of all living genera. Modifying Other’s Originality without Quote is an Act of Piracy A writer who does not cite the sources in h/h feature article is committing piracy. Piracy is…

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MicroRNAs biophysically constrain behavior

February 28, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA methylation, RNA-directed DNA methylation, Variations
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The link from the quantized energy of sunlight to the creation of microRNAs and biophysically constrained morphological phenotypes has been clear since 1944, when Schroedinger placed it into the context of “What is Life?”. In the reprint edition, Roger Penrose added: “How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991) Unfortunately for those who have…

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An evolutionary theory killer

A reversible TCA cycle in a thermophile (3)

February 9, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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A pathway for mitotic chromosome formation The combination of nested loops distributed around a helically twisted axis plus dense chromatin packing achieves the 10,000-fold compaction of chromatin into linearly organized chromosomes that is required for accurate chromosome segregation when cells divide. The compaction of chromatin in the context of hydrophobicity is the topic of: Structural diversity of supercoiled DNA Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural…

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An evolutionary theory killer

A reversible TCA cycle in a thermophile (2)

February 9, 2018
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation
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Summary: The energy-dependent creation of ATP has been linked from the energy-dependent creation of RNA to feedback loops that link the pheromone-controlled physiology of reproduction to biodiversity in species from microbes to humans via olfaction and pheromones. Anyone who continues to try to place the facts into the context of brain stimulation by visual input and ignore the facts about how the creation of microRNAs must be linked from creation of the sense of smell to all biophysically constrained viral…

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Anti-entropic sunlight: Schrödinger’s Creationist Secret? (1)

February 1, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA-directed DNA methylation, Variations
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Summary: Perhaps Daniel Dennett will make people feel better about the unnecessary suffering and premature death. Daniel Dennett is scheduled to present the Keynote Lecture at Schrödinger at 75 – The Future of Biology – September 2018 For insight into his philosophical perspective see: How to Criticize with Kindness: Philosopher Daniel Dennett on the Four Steps to Arguing Intelligently 1) You should attempt to re-express your target’s position so clearly, vividly, and fairly that your target says, “Thanks, I wish…

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The MicroRNAome Strikes Back: A Sokalian hoax (9)

January 31, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Darwin’s “conditions of life” link the creation of sunlight from the creation of ATP to the creation of microRNAs and RNA-mediated cell type differentiation in the context of biophysically constrained viral latency. There is no magical creation of an RNA force field or protein force field that could be used to link the magic of evolution to biologically-based diversity in species from microbes to humans. RNA force field with accuracy comparable to state-of-the-art protein force fields The complex and…

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http://nnjournal.net/article/viewFile/2354/1850/10234

Diet-driven RNA interference and mental health (2)

January 26, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Diseases & Disorders, Ecology, RNA Directed
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The diet-driven construction of the competing endogenous RNA networks (ceRNA networks) is energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. Viruses compete for the energy, which is how they contribute to the degradation of messenger RNA that all serious scientists have linked to all mental and physical pathology. Cell death is not just seen in the context of autophagy and neural cell death. The pathogens that alter physiology also alter behavior via the conserved molecular mechanisms of energy-dependent…

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