microtubules

Plenty of Room at the Bottom

Cryo-EM: Linking spatial and conformational constraints

On Darwin Day (2018) Carl Zimmer suggested use of the twitter hashtag #Istudyevolution to report whatever aspect of biology people were studying. For example, Richard Lenski reported that he studied adaptation in E. coli. When I told others that ecological adaptation is nutrient-dependent and pheromone-controlled in species from microbes to humans, he blocked me from seeing his comments. Evidently he did not want people to know that he had been studying ecological adaptation for more than 2 decades but reporting…

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A Mathematical Model Links Quantum Physics to Quantum Souls (1)

Historical facts: All energy-dependent cell type differentiation is biophysically constrained by the de novo creation of microRNAs and enzymes that metabolize food and drugs. All food energy-dependent metabolism occurs in the context of microRNA-mediated cause and effect and the physiology of pheromone-controlled reproduction. The food energy-dependent pheromone controlled physiology of reproduction in bacteria links what organisms eat to the transgenerational epigenetic inheritance of their morphological and behavioral phenotypes. The virus-driven degradation of messenger RNA has been linked to all pathology…

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From base editing to RNA editing (8)

Excerpt: See: Quantum Vacuum Dynamics, Coherence, Superluminal Photons and Hypercomputation in Brain Microtubules Finally, these theorists attempt to link the speed of light on contact with water (Darwin’s “conditions of life”) to all biophysically constrained biodiversity. Researchers find potential path to repair multiple sclerosis-damaged nerves December 26, 2017 Multiple sclerosis is an autoimmune, neurodegenerative disease, characterized by distinct disabilities affecting walking, vision, and cognition, to name a few. MS patients differ markedly from each other regarding which disability affects them…

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A null mutation and healthy longevity?

Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia Reported as: How to Control…

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From E. coli to monkeys and mankind: Theories vs models (4)

From E. coli to monkeys and mankind: Theories vs models (3)  More Complexity with Tau Tagging and un tagging occurs at Ser214, Thr231 and Ser262 at least in order to attach to microtubules in good neurons along the axon highways. Interactions of these affect the PSD as well such as Ser212/Thr214, Ser202/Thr205, and Thr231 by altering the tau interaction with the PSD. Tau is called a “microtubule associated protein”, one of many stabilizing and regulating the vast amount of shapes…

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pH, water, amino acids and protein folding

Solubilities of amino acids in water at various pH values under 298.15 K and Translational tuning optimizes nascent protein folding in cells link what is currently known about the biophysically constrained chemistry of nutrient-dependent RNA-mediated protein folding to cell type differentiation in all genera via conserved molecular mechanisms.  Mutations are linked from perturbed protein folding to pathology. See for example: From “Science Mission” 5/2/15 at 12 pm Water diffusion and neurodegenerative disease linked to Hydration water mobility is enhanced around tau…

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The quantum / classical RNA-mediated ‘tipping point’

Researchers identify ‘tipping point’ between quantum and classical worlds Excerpt: “Any popular explanation of quantum theory usually begins with Schroedinger’s cat – a thought experiment describing a cat inside a closed box, that may be either dead or alive,” Vered says. “Rather than looking at the tipping-point between life and death, our experiment examines the point at which quantum behavior gives way to classical physics. Since quantum behavior kicks in at a very small scale, one could liken our results…

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