molecular

Ecological law, cooperation, and DNA repair

Ecological laws: what would they be and why would they matter? Abstract excerpt: … I argue, the existence of ecological laws would make ecological explanations irreducible to even the most complete possible physical explanations of the same phenomena. Ecological laws would make ecology genuinely autonomous from physics. My comment: This is a fool’s argument.  Serious scientists know physics and chemistry must be linked to biophysically constrained nutrient-dependent RNA-mediated protein folding chemistry. The links must be placed into the context of…

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Unified nutritional and molecular mechanisms

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits Article image: Excerpt: “…unifying nutritional and molecular mechanisms remain elusive.” Reported as Molecular mechanism behind health benefits of dietary restriction identified Excerpt 1) “Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been…

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It’s cell type differention, not cell fate determination (2)

See: It’s cell type differention, not cell fate determination High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions Excerpt: “…deviation from the derived models is a characteristic hallmark of methylation changes associated with cancer states suggesting that this phenomenon is mechanistically distinct from differentiation related methylation changes.” My comment: The article helps to detail the difference between facts about the molecular mechanisms of RNA-mediated events that lead to cell type differentiation and theories…

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Did our adapted mind evolve? (Revisited)

Did our adapted mind evolve? In my extended comments on this topic I concluded with “Experience-dependent changes in DNA methylation can exert profound effects on neuronal function and behaviour. A single learning event can induce a variety of DNA modifications within the neuronal genome, some of which may be common to all individuals experiencing the event, whereas others may occur in a subset of individuals.” The experience-dependent changes are due to RNA-directed DNA methylation (i.e., RNA-mediated events, not evolutionary events).…

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New technique used in report of atomic-level ecological adaptations

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons Directed evolution of a far-red fluorescent rhodopsin reported as: New technique uses a genetic tool and light to view and map neuronal circuits Excerpt 1): “This [directed evolution] experiment demonstrates how rapidly these remarkable bacterial proteins can evolve in response to new demands. But even more exciting is what they can do in neurons, as Viviana discovered,” says Arnold. Excerpt 2): After incorporating Archer1 into neurons that were…

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Quantum physics meets Evolutionary Psychology News

Capturing the motion of a single molecule in real time as it oscillates from one quantum state to another September 18, 2014 Excerpt: “It also moves researchers a step closer to viewing the molecular world in action — being able to see the making and breaking of bonds, which control biological processes such as enzymatic reactions and cellular dynamics.” My comment: The making and breaking of bonds controls all biological processes. Luca Turin tried to do move researchers a step closer…

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Nutrient-dependent pheromone-controlled exercise-induced physiques

How to explain exercise-induced phenotype from molecular data: rethink and reconstruction based on AMPK and mTOR signaling Excerpt: “…cellular and molecular phenotype for exercise capacity is always acquired from regular exercise or muscle contraction; it is absurd to use drug and gene modification…” My comment: What is known about RNA-mediated events shows that the slightest deficit in nutrient uptake will be manifested in your exercise-induced physique, which is also epigenetically-effected by the pheromones of others via the same pathway. Meanwhile,…

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A molecular visualizer of worthwhile molecular biology

Ruben Gonzalez Jr.: Molecular Visualizer Associate Professor and Director of Graduate Studies, Department of Chemistry, Columbia University. Age 42 By Jef Akst | September 1, 2014 Excerpt: “Much of his group’s current work involves extending discoveries about translation in E. coli to the process in eukaryotes, with an eye toward human health and disease.” My comment: That sums up the frustration that other serious scientists must share when they hear pseudoscientific nonsense touted about mutations, natural selection, and the evolution…

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RNA-mediated ecological adaptation is not evolution

Prehistoric Critters Change View of Mammal Evolution Three extinct squirrel-like species were identified from Jurassic-era fossils in China. By Molly Sharlach | September 12, 2014 Excerpt 1): “The fossils suggest that the slender animals spent time in trees, and had hands and feet adapted for grabbing branches. Their resemblance to present-day squirrels is a result of convergent evolution, as they belong to a lineage that diverged from that of modern mammals long ago.” My comment: Resemblance in the fossil record…

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Behavior: The first response is RNA-mediated not genetically-determined

Diana Maria Petrosanu asked a question in an Evolutionary Psychology News discussion about Evolution’s Random Paths Lead to One Place. I’ve been very vocal in other discussions that tout ridiculous theories that have been repeatedly refuted by biological facts. My answer to her question might help others to understand the language of RNA-mediated events. That’s why I added details to my representation at Combating Evolution to Fight Disease.  Whether or not the addition to my comments is published or understood…

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