Communication shapes sensory response in multicellular networks Significance Cells routinely sense and respond to their environment, and they also communicate with each other. Exactly how communication impacts sensing remains poorly understood. We study a population of fibroblast cells that responds to a chemical stimulus (ATP) and communicates by molecule exchange. Combining experiments and mathematical modeling, we find that cells exhibit calcium oscillations in response to not only the ATP stimulus but also, increased cell–cell communication. Our results show that, when…