mRNA

Defeating disease and Communism (3)

More than 117,000 published works that mention ‘microRNA‘ can be linked from: Playing games with quantum interference 3/10/21 via MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 to the game for ages 14+ Genotype. Everything known to intelligent serious scientists has been linked to Thomas Hunt Morgan’s claims about chromosomal rearrangements and sympatric speciation in flies and other insects. See also: Hypoxia associated multi-omics molecular landscape of tumor tissue…

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Misleading evidence, Raman Hyperspectroscopy and FB jail

Yesterday, on the topic of vaccines used to prevent Ebola virus transmission, I wrote: …. There is no such thing as an extinct virus. Their ability to steal energy is biophysically constrained until nutrient stress and/or social stress cause their reactivation. I provided a link to The Darwin Code Today, I read about The misleading evidence that fooled scientists for decades After posting this comment to “The Conversation,” I learned I was blocked from posting anything to Facebook. Have you considered…

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From photons to the proton motive force (2)

If you know someone who has linked differences in the energy of photons from the proton motive force to the physiology of reproduction and all biophysically constrained biodiversity, ask if they will attend Schrödinger at 75-The Future of Biology For contrast, touting genetic evolution is not the future of biology. See: Abstract: K06.00013 : A Path Integral Method for Analytically Tractable Inference of Evolutionary Dynamics Understanding the forces that shape genetic evolution is a subject of fundamental importance in biology…

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An evolutionary theory killer

Conceptual critique: Innateness vs the death gene (2)

Excerpt: Martie Haselton notes “…there’s a hidden adaptive intelligence that has been shaped over eons. Martie Haselton places that ecological adaptation into the context of the claim that “…our bodies are designed to fight off invaders, whether they take the form of a cold virus… (p 73.) and she mentions the link from the designer to one theory about menstruation: “female bleeding serves to flush out “bad” sperm that may carry bacteria, viruses and other pathogens.” (p. 84) See also:…

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Autophagy is the antiphage defense strategy (2)

2/15/17 Energy as information and constrained endogenous RNA interference (video) The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked: 12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore 12/25/17 Replying to @nikwillmore @jhewitt123 God created the anti-entropic virucidal energy of sunlight and…

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UV light and non-coding RNA

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene …these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. Intriguingly, the switch between ASCC3 isoforms occurs on more than one level, in that the long mRNA isoform encodes a protein, functioning in the context of the ASCC complex and required for maintaining transcriptional suppression in the late stages of…

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Fighting for virus-driven pathology

See my series of 5 posts on the tipping point, which was reached when more than 50,000 indexed publications mentioned microRNAs The tipping point? 50, 000 publications May 16, 2016 See also: MicroRNA analysis in mouse neuro-2a cells after pseudorabies virus infection A total of eight viral miRNA were identified, and ten host miRNAs showed significantly different expression upon PRV infection. Among these, five were analyzed by stem-loop RT-qPCR, which confirmed the above data. Interestingly, these viral miRNAs were mainly…

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Re-inventing mutation-driven evolution (2)

See: Re-inventing mutation-driven evolution See also: Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp … we suspected that splicing efficiency, as defined by the fraction of pre-mRNA converted into mature mRNA, must have contributed to temperature-dependent Cirbp mRNA accumulation Splicing efficiency is energy-dependent in the context of temperature-dependent oscillations that link the sun’s anti-entropic virucidal energy to all biodiversity via Turing’s claims and my model. See also: The B/Z reaction, and the problem with peer review In…

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Sudden death indel polymorphism

An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations. …different alleles of rs10692285 could alter the local structure of RYR2 mRNA and microRNA (miRNA) binding. See for comparison: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant The differences between the 370A knockin mouse phenotypes and those of loss- and gain-of-function models emphasize the advantage of a more accurate mouse model. In this study an adaptive variant links the mouse…

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Biophotonics, glycobiology, quantized biodiversity

Historical perspective: From Fertilization to Adult Sexual Behavior Excerpt: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may…

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