mutagenesis

Energy-dependent alternative splicings 1996 – 2016

Highlights: 1) Alternative splicings of messenger RNA link the sun’s anti-entropic virucidal energy as information to DNA repair. 2) DNA repair links fixation of amino acid substitutions in supercoiled DNA to healthy longevity. 3) Supercoiled DNA protects all organized genomes from virus-driven energy theft and genomic entropy. 4) Genomic entropy is less likely to occur in the context of the physiology of reproduction and transgenerational epigenetic inheritance of ecologically adapted morphological and behavioral phenotypes. 5) Preventing virus-driven energy theft from…

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More refutations of neo-Darwinian nonsense

New CRISPR–Cas systems from uncultivated microbes In bacteria, we discovered two previously unknown systems, CRISPR-CasX and CRISPR-CasY, which are among the most compact systems yet identified. Notably, all required functional components were identified by metagenomics, enabling validation of robust in vivo RNA-guided DNA interference activity in E. coli. Interrogation of environmental microbial communities combined with in vivo experiments allows access to an unprecedented diversity of genomes whose content will expand the repertoire of microbe-based biotechnologies. They discovered that energy-dependent RNA-mediated…

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Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Genes, orchid odors, and pheromones from blonds

1) The Genetics of Blond Hair (2014) and 2) Orchids give off human ‘body odor’ to attract mosquitoes (2016) Both articles link RNA-mediated cell type differentiation in all invertebrates and all vertebrates to every aspect of cell type differentiation in plants. …studies of genetic variation in thousands of people have linked at least eight DNA regions to blondness based on the fact that a certain DNA letter, or base, was found in people with that hair color but not in…

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Thermodynamic constraints did not evolve

My model links the biophysically constrained fixation of nutrient-dependent RNA-mediated amino acid substitutions to the stability of organized genomes. Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Nutrient-dependent pheromone-controlled stability of organized genomes has since been placed into the context of anti-aging medicine, as I did in presentations from 1994 and 1995. See: Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction, which was reported as: Immortality is one step closer as scientists turn off the ageing…

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The biologically-based origin of the mammalian placenta (2)

See also: The biologically-based origin of the mammalian placenta I’ll preface this follow-up on the origins of the mammalian placenta with comments that attest to foolishness of theoretical physicists who try to link Big Bang cosmology to neo-Darwinian theories about mutations and evolution. RPF Interviews Dr. Alexander Unzicker Excerpt 1)  “It annoys me too much to see another generation of physicists deterred by the dumb messy patchwork called the standard model of particle physics, that hides the basic problems physics…

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RNA-mediated genetic engineering (Part 2)

WATCH: Bill Nye the Science Guy predicts end of creationism is nigh Excerpt: “Best known as Bill Nye the Science Guy, the 58-year-old educator, TV personality and author lamented the lingering myth that the universe is a product of divine creation.” My comment: Evolutionary theorists have not described a biologically-based evolutionary event that links one species to the evolution of another. The myth of evolution was exposed via the fact that Richard Lenski’s bacteria and Michael Desai’s yeasts did not…

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