natural selection

Targeting a cancer gene

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous masterminds of malignancies.” and see K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions [subscription required] Excerpt: “…initial evaluation of our compounds in lung cancer cell lines suggests allele-specific impairment of K-Ras function.” My comment: 1) They ignored any aspect…

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Social experiences epigenetically effect gene networks

Networks of Genes Respond to Social Experiences October 13, 2013, from Searching for the Mind with Jon Lieff, M.D. Excerpt 1: “The gene networks of social experience are consistent through many animals.” My comment: Not just many animals; the gene networks of social experiences must be consistent in all animals that adaptively evolved. You cannot get from microbes to man with any consistent model of cause and effect until you realize that the molecular mechanisms that enable cause and effect…

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Evolution: innovations may have non-adaptive origins (sans mutations)

Q & A: Evolution Makes Do By Chris Palmer Evolutionary biologist Andreas Wagner argues that many evolutionary innovations may have non-adaptive origins. Excerpt: “If exaptations are pervasive, then natural selection—which few doubt is critical for the preservation and spreading of traits—may not be that important for the origin of innovations in life’s history.” See also: Rapid detection of positive selection in genes and genomes through variation clusters Excerpt: “They occur in well-defined domains of a protein’s tertiary structure and show…

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