natural selection

For God and Country

Abiogenesis vs microRNA biogenesis (2)

April 20, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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All serious scientists learned about Schrödinger’s claims in “What is Life?” (1944).  All serious scientists have since linked the creation of the sun’s anti-entropic virucidal energy to “negentropy” and healthy longevity. See also: Reappraising the human mitochondrial DNA recombination dogma …paving the way for the definitive rejection of the non-recombination dogma for human mtDNA.   Recombination is quantized energy-dependent and biophysically constrained by the physiology of reproduction. See the works of those who are scheduled to present during Schrödinger at…

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From photons to the proton motive force (2)

March 9, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, What's in the News
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If you know someone who has linked differences in the energy of photons from the proton motive force to the physiology of reproduction and all biophysically constrained biodiversity, ask if they will attend Schrödinger at 75-The Future of Biology For contrast, touting genetic evolution is not the future of biology. See: Abstract: K06.00013 : A Path Integral Method for Analytically Tractable Inference of Evolutionary Dynamics Understanding the forces that shape genetic evolution is a subject of fundamental importance in biology…

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The MicroRNAome Strikes Back: A Sokalian hoax (8)

January 30, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Defeating Diseases with Energy (January 9, 2018) is a thinly disguised attempt to help corporate giants continue to promote ridiculous neo-Darwinian theories. It features the works of Douglas C. Wallace, who failed to link the virus-driven degradation of messenger RNA to all pathology since he published: Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes (1990). Similar analysis of a cervical carcinoma (HeLa), fibrosarcoma (HT1080), and an Epstein-Barr virus (EBV)-transformed lymphoblastoid line (EBV-L) revealed that…

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The MicroRNAome Strikes Back: A Sokalian hoax (6)

January 25, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, RNA Directed
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The nature of nurture: Effects of parental genotypes Science  January 26, 2018 …nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call “genetic nurture.” It doesn’t matter what they call it, since there is no defined boundary between genetics and epigenetics. Reported as: You Are Shaped by the Genes You Inherit. And Maybe by Those You Don’t by Carl Zimmer January 25, 2018 A calf may inherit those milk-boosting variants from its mother. But…

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Diet-driven RNA interference and cancer prevention

January 14, 2018
James Kohl
RNA Directed
One Comment

The food energy-dependent creation of one enzyme is the key to the effective treatment and/or prevention of colorectal cancer. The creation of enzymes prevents the creation of viral microRNAs. The food energy-dependent creation of one or more enzymes limits the ability of different viruses to steal more quantized energy. That is the basis for my claims about biophysically constrained viral latency. Moreover, all pathology is caused by the virus-driven degradation of messenger RNA. See: Engineered commensal microbes for diet-mediated colorectal-cancer…

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Enzyme-constrained interethnic biodiversity (6)

January 12, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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I think that I may be able to finish this series before the end of the month and use my tweets to expose more than 100,000  people to what is known about how the energy-dependent creation of microRNAs prevents all pathology. See for one example of more than 68,000 published works: MicroRNA-22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3 For an extensive review of biologically-based biophysically constrained viral latency, see: Enzyme-constrained interethnic biodiversity…

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From Autophagy.pro (transitions)

December 15, 2017
James Kohl
RNA Directed
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Summary: Who lets biologically uninformed theorists make presumptions about evolution after all serious scientists have linked light-harvesting from energy-dependent changes in electrons to ecosystems in all living genera via natural selection for food energy-dependent codon optimality. Who lets them pretend not to know that the pheromone-controlled physiology of reproduction links autophagy to the transgenerational epigenetic inheritance of healthy longevity? Who is causing the unnecessary suffering and premature death of your loved ones? Elsevier publishing supports the pseudoscientific nonsense touted by…

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Two retractions of human idiocy

December 7, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
One Comment

Excerpt: …she was interested in the PNAS research because it identified a potential inhibitor of the hepatitis C virus… ”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal 1) This retraction marks the second in six months for Nature Chemistry after having none for eight years. 2) In 2009, Szostak also retracted a 2008 paper in Proceedings of the National Academy of Sciences after an outside researcher could not replicate the results. The retraction notice credited Katherine Berry, then…

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Pheromones biophysically constrain base editing and RNA editing

November 2, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, What's in the News
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Summary: …they [Koonin’s group] substitute what they consider to be a plausible hypothesis. It places their observations into the context of a universal trend that is conserved in all life after the trend emerged, which was sometime before the last universal common ancestor of all extant organisms emerged and began to evolve. Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex Published online 18 October 2017 The vibrational theory of olfaction for the win Published 31 October 2017 Neuronal…

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Lethal virus kills 5 billion people?

Entertaining yourself to death

October 5, 2017
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Neuronal Plasticity, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Food energy is required for the creation of enzymes that metabolize the food, which links the metabolism to the pheromone-controlled physiology of reproduction in species from microbes to humans via alternative splicings of pre-mRNAs, which are now called microRNAs in more than 65,000 published works. The horrid tradjedy of of yet another preventable death by suicide extends those works to preventing the cause of death of those killed by Stephen Paddock. Vegas gunman transferred $100K, set up cameras at…

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